J
Joseph M. McCune
Researcher at Bill & Melinda Gates Foundation
Publications - 298
Citations - 34485
Joseph M. McCune is an academic researcher from Bill & Melinda Gates Foundation. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 97, co-authored 296 publications receiving 31120 citations. Previous affiliations of Joseph M. McCune include San Francisco General Hospital & Johns Hopkins University.
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Journal ArticleDOI
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes
Matthew H. Liang,Michael Corzillius,Sang Cheol Bae,Robert A. Lew,Paul R. Fortin,Caroline Gordon,David A. Isenberg,Graciela S. Alarcón,Karin V. Straaton,Judah A. Denburg,Susan D. Denburg,John M. Esdaile,Bonnie I. Glanz,Elizabeth W. Karlson,Shahram Khoshbin,Malcolm P. Rogers,Peter H. Schur,John G. Hanly,Elizabeth Kozora,Sterling G. West,Robert G. Lahita,Michael D. Lockshin,Joseph M. McCune,Patricia M. Moore,Michelle Petri,W. Neal Roberts,Jorge Sánchez-Guerrero,Martin Veilleux,Robin L. Brey,Wayne D. Cornblath,Christopher M. Filley,John D. Fisk,Pontus Harten,Elaine M. Hay,Grant L. Iverson,Steven R. Levine,Elizabeth Waterhouse,Daniel J. Wallace,John B. Winer +38 more
TL;DR: The American College of Rheumatology Nomenclature for NPSLE provides case definitions for 19 neuropsychiatric syndromes seen in SLE, with reporting standards and recommendations for laboratory and imaging tests.
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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
TL;DR: Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency.
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2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
Martin Aringer,Karen H. Costenbader,David I. Daikh,Ralph Brinks,Marta Mosca,Rosalind Ramsey-Goldman,Josef S Smolen,David Wofsy,Dimitrios T. Boumpas,Diane L. Kamen,David Jayne,Ricard Cervera,Nathalie Costedoat-Chalumeau,Betty Diamond,Dafna D. Gladman,Bevra H. Hahn,Falk Hiepe,Søren Jacobsen,Dinesh Khanna,Kirsten Lerstrøm,Elena Massarotti,Joseph M. McCune,Guillermo Ruiz-Irastorza,Jorge Sanchez-Guerrero,Matthias Schneider,Murray B. Urowitz,George Bertsias,Bimba F. Hoyer,Nicolai Leuchten,Chiara Tani,Sara K. Tedeschi,Zahi Touma,Gabriela Schmajuk,Branimir Anić,Florence Assan,Tak Mao Chan,Ann E. Clarke,Mary K. Crow,László Czirják,Andrea Doria,Winfried Graninger,Bernadett Halda-Kiss,Sarfaraz Hasni,Peter M. Izmirly,Michelle Jung,Gábor Kumánovics,Xavier Mariette,Ivan Padjen,José M. Pego-Reigosa,Juanita Romero-Diaz,Íñigo Rúa-Figueroa Fernández,Raphaèle Seror,Georg Stummvoll,Yoshiya Tanaka,Maria G Tektonidou,Carlos Vasconcelos,Edward M Vital,Daniel J. Wallace,Sule Yavuz,Pier Luigi Meroni,Marvin J. Fritzler,Ray Naden,Thomas Dörner,Sindhu R. Johnson +63 more
TL;DR: To develop new classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism and the American College of Rheumatology (ACR).
Journal ArticleDOI
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Jeff E. Mold,Jakob Michaëlsson,Trevor D. Burt,Marcus O. Muench,Karen P. Beckerman,Michael P. Busch,Tzong-Hae Lee,Douglas F. Nixon,Joseph M. McCune +8 more
TL;DR: It is found that substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the development of regulatory T cells (Tregs) that suppress fetal antimaternal immunity and persist at least until early adulthood.
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Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
R. Brad Jones,Lishomwa C. Ndhlovu,Jason D. Barbour,Prameet M. Sheth,Aashish R. Jha,Brian Long,Jessica Wong,Malathy Satkunarajah,Marc Schweneker,Joan M. Chapman,Gabor Gyenes,Bahareh Vali,Martin D. Hyrcza,Feng Yun Yue,Colin Kovacs,Aref Sassi,Mona R. Loutfy,Roberta Halpenny,Desmond Persad,Gerald Spotts,Frederick Hecht,Tae-Wook Chun,Joseph M. McCune,Rupert Kaul,James M. Rini,Douglas F. Nixon,Mario A. Ostrowski +26 more
TL;DR: Blocking the Tim-3 signaling pathway restored proliferation and enhanced cytokine production in HIV-1–specific T cells and represents a novel target for the therapeutic reversal of HIV–1–associated T cell dysfunction.