D
Dennis W. Choi
Researcher at Stony Brook University
Publications - 247
Citations - 51780
Dennis W. Choi is an academic researcher from Stony Brook University. The author has contributed to research in topics: Glutamate receptor & NMDA receptor. The author has an hindex of 99, co-authored 243 publications receiving 50284 citations. Previous affiliations of Dennis W. Choi include Merck & Co. & Stanford University.
Papers
More filters
Journal ArticleDOI
Excitotoxic cell death
TL;DR: On average, NMDA receptors activation may be able to trigger lethal injury more rapidly than AMPA or kainate receptor activation, perhaps reflecting a greater ability to induce calcium influx and subsequent cellular calcium overload.
Journal ArticleDOI
The role of glutamate neurotoxicity in hypoxic- ischemic neuronal death
Dennis W. Choi,Steven M. Rothman +1 more
TL;DR: A critical question has been why brain, more than mostother tissues, is so vulnerable to hypoxic-ischemic insults, and at least some of this special vulnerability may be accounted for by the central neurotoxicity of the endogenous excitatory
Journal ArticleDOI
Ionic dependence of glutamate neurotoxicity
TL;DR: The results suggest that GNT in cortical neurons can be separated into 2 components distinguishable on the basis of differences in time course and ionic dependence, and the notion that the activation of voltage- dependent Ca channels may not be required for lethal Ca entry is supported.
Journal ArticleDOI
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.
TL;DR: Current efforts to develop an effective therapy for hypoxic-ischemic neuronal injury are appropriately focused onNMDA antagonists; however, it is possible that additional benefit might be gained by combining NMDA antagonists with pharmacological manipulations designed to attenuate Ca 2+ entry through these other routes.