D
Derek D. Yang
Researcher at Yale University
Publications - 18
Citations - 7184
Derek D. Yang is an academic researcher from Yale University. The author has contributed to research in topics: Signal transduction & Mitogen-activated protein kinase. The author has an hindex of 18, co-authored 18 publications receiving 7026 citations. Previous affiliations of Derek D. Yang include Eli Lilly and Company & University of Massachusetts Medical School.
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Journal ArticleDOI
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Cathy Tournier,Patricia M. Hess,Derek D. Yang,Jie Xu,Tod K. Turner,Anjaruwee S. Nimnual,Dafna Bar-Sagi,Stephen N. Jones,Richard A. Flavell,Roger J. Davis +9 more
TL;DR: It is shown here that JNK is required for UV-induced apoptosis in primary murine embryonic fibroblasts, and data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway.
Journal ArticleDOI
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Derek D. Yang,Chia-Yi Kuan,Alan J. Whitmarsh,Alan J. Whitmarsh,Mercedes Rincon,Timothy S. Zheng,Roger J. Davis,Roger J. Davis,Pasko Rakic,Richard A. Flavell +9 more
TL;DR: It is reported that disruption of the gene encoding Jnk3 in mice caused the mice to be resistant to the excitotoxic glutamate-receptor agonist kainic acid and neuroprotection was prevented: they showed a reduction in seizure activity and hippocampal neuron apoptosis was prevented.
Journal ArticleDOI
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
Chia-Yi Kuan,Derek D. Yang,Deborah R. Samanta Roy,Roger J. Davis,Pasko Rakic,Richard A. Flavell +5 more
TL;DR: It is suggested that Jnk1 andJnk2 regulate region-specific apoptosis during early brain development by reducing cell death in the lateral edges of hindbrain prior to neural tube closure and increasing apoptosis and caspase activation in the mutant forebrain.
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Defective T cell differentiation in the absence of Jnk1
TL;DR: The JNK1 signaling pathway plays a key role in T cell receptor-initiated TH cell proliferation, apoptosis, and differentiation in mice bitten by Jnk1-/- mice.
Journal ArticleDOI
Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2
Derek D. Yang,Dietrich Conze,Alan J. Whitmarsh,Tamera Barrett,Roger J. Davis,Mercedes Rincon,Richard A. Flavell +6 more
TL;DR: The addition of exogenous IFNgamma during differentiation restores IL-12-mediated Th1 polarization in the JNK2-deficient mice and plays an important role in the balance of Th1 and Th2 immune responses.