C
Charles A. Mein
Researcher at Queen Mary University of London
Publications - 123
Citations - 10816
Charles A. Mein is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Population & Gene. The author has an hindex of 45, co-authored 116 publications receiving 9915 citations. Previous affiliations of Charles A. Mein include Wellcome Trust Centre for Human Genetics & Sapienza University of Rome.
Papers
More filters
Journal ArticleDOI
Multiple common variants for celiac disease influencing immune gene expression
Patrick Dubois,Gosia Trynka,Lude Franke,Lude Franke,Karen A. Hunt,Jihane Romanos,Alessandra Curtotti,Alexandra Zhernakova,Graham A. Heap,Róza Ádány,Arpo Aromaa,Maria Teresa Bardella,Leonard H. van den Berg,Nicholas A. Bockett,Emilio G. de la Concha,Bárbara Dema,Rudolf S N Fehrmann,Miguel Fernández-Arquero,Szilvia Fiatal,Szilvia Fiatal,Elvira Grandone,Peter M. Green,Harry J.M. Groen,Rhian Gwilliam,Roderick H. J. Houwen,Sarah E. Hunt,Katri Kaukinen,Dermot Kelleher,Ilma Rita Korponay-Szabó,Kalle Kurppa,Padraic MacMathuna,Markku Mäki,Maria Cristina Mazzilli,Owen T. McCann,M. Luisa Mearin,Charles A. Mein,Muddassar M. Mirza,Vanisha Mistry,Barbara Mora,Katherine I. Morley,Chris J. J. Mulder,Joseph A. Murray,Concepción Núñez,Elvira Oosterom,Roel A. Ophoff,Roel A. Ophoff,Isabel Polanco,Leena Peltonen,Leena Peltonen,Mathieu Platteel,Anna Rybak,Veikko Salomaa,Joachim J. Schweizer,Maria Pia Sperandeo,Greetje J. Tack,Graham Turner,Jan H. Veldink,Wieke H. M. Verbeek,Rinse K. Weersma,Victorien M. Wolters,Elena Urcelay,Bożena Cukrowska,Luigi Greco,Susan L. Neuhausen,Ross McManus,Donatella Barisani,Panos Deloukas,Jeffrey C. Barrett,Päivi Saavalainen,Cisca Wijmenga,David A. van Heel +70 more
TL;DR: This article performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects, and genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls.
Multiple common variants for celiac disease influencing immune gene expression
Patrick Dubois,Gosia Trynka,Lude Franke,Lude Franke,Karen A. Hunt,Jihane Romanos,Alessandra Curtotti,Alexandra Zhernakova,Graham A. Heap,Róza Ádány,Arpo Aromaa,Maria Teresa Bardella,Leonard H. van den Berg,Nicholas A. Bockett,Emilio G. de la Concha,Bárbara Dema,Rudolf S N Fehrmann,Miguel Fernández-Arquero,Szilvia Fiatal,Szilvia Fiatal,Elvira Grandone,Peter M. Green,Harry J.M. Groen,Rhian Gwilliam,Roderick H. J. Houwen,Sarah E. Hunt,Katri Kaukinen,Dermot Kelleher,Ilma Rita Korponay-Szabó,Kalle Kurppa,Padraic MacMathuna,Markku Mäki,Maria Cristina Mazzilli,Owen T. McCann,M. Luisa Mearin,Charles A. Mein,Muddassar M. Mirza,Vanisha Mistry,Barbara Mora,Katherine I. Morley,Chris J. J. Mulder,Joseph A. Murray,Concepción Núñez,Elvira Oosterom,Roel A. Ophoff,Roel A. Ophoff,Isabel Polanco,Leena Peltonen,Leena Peltonen,Mathieu Platteel,Anna Rybak,Veikko Salomaa,Joachim J. Schweizer,Maria Pia Sperandeo,Greetje J. Tack,Graham Turner,Jan H. Veldink,Wieke H. M. Verbeek,Rinse K. Weersma,Victorien M. Wolters,Elena Urcelay,Bożena Cukrowska,Luigi Greco,Susan L. Neuhausen,Ross McManus,Donatella Barisani,Panos Deloukas,Jeffrey C. Barrett,Päivi Saavalainen,Cisca Wijmenga,David A. van Heel +70 more
TL;DR: Variants from 13 new regions reached genome-wide significance and most contain genes with immune functions, with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection.
Journal ArticleDOI
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Gosia Trynka,Karen A. Hunt,Nicholas A. Bockett,Jihane Romanos,Vanisha Mistry,Agata Szperl,Sjoerd F. Bakker,Maria Teresa Bardella,Leena Bhaw-Rosun,Gemma Castillejo,Emilio G. de la Concha,Rodrigo Coutinho de Almeida,Kerith-Rae Dias,Cleo C. van Diemen,Patrick Dubois,Richard H. Duerr,Sarah Edkins,Lude Franke,Karin Fransen,Javier Gutierrez,Graham A. Heap,Barbara Hrdličková,Sarah E. Hunt,Leticia Plaza Izurieta,V. Izzo,Leo A. B. Joosten,Cordelia Langford,Maria Cristina Mazzilli,Charles A. Mein,Vandana Midah,Mitja Mitrovic,Barbara Mora,Marinita Morelli,Sarah Nutland,Concepción Núñez,Suna Onengut-Gumuscu,Kerra Pearce,Mathieu Platteel,Isabel Polanco,Simon C. Potter,Carmen Ribes-Koninckx,Isis Ricaño-Ponce,Stephen S. Rich,Anna Rybak,Jose Luis Santiago,Sabyasachi Senapati,Ajit Sood,Hania Szajewska,Riccardo Troncone,Jezabel Varadé,Chris Wallace,Victorien M. Wolters,Alexandra Zhernakova,B.K. Thelma,Bożena Cukrowska,Elena Urcelay,Jose Ramon Bilbao,M. Luisa Mearin,Donatella Barisani,Jeffrey C. Barrett,Vincent Plagnol,Panos Deloukas,Cisca Wijmenga,David A. van Heel +63 more
TL;DR: The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease.
Journal ArticleDOI
Newly identified genetic risk variants for celiac disease related to the immune response
Karen A. Hunt,Alexandra Zhernakova,Graham Turner,Graham A. Heap,Lude Franke,Marcel Bruinenberg,Jihane Romanos,Lotte C. Dinesen,Anthony W. Ryan,Davinder Panesar,Rhian Gwilliam,Fumihiko Takeuchi,William M. McLaren,Geoffrey Holmes,Peter D. Howdle,Julian R.F. Walters,David S Sanders,Raymond J. Playford,Gosia Trynka,Chris J. J. Mulder,M. Luisa Mearin,M. Luisa Mearin,Wieke H. M. Verbeek,Valerie Trimble,Fiona M. Stevens,Colm O'Morain,Nicholas P. Kennedy,Dermot Kelleher,Daniel J. Pennington,David P. Strachan,Wendy L. McArdle,Charles A. Mein,Martin C. Wapenaar,Panos Deloukas,Ralph McGinnis,Ross McManus,Cisca Wijmenga,Cisca Wijmenga,David A. van Heel +38 more
TL;DR: This extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways and identified seven previously unknown risk regions.
Journal ArticleDOI
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
Jessica Okosun,Csaba Bödör,Jun Wang,Shamzah Araf,Cheng Yuan Yang,Chenyi Pan,Sören Boller,Davide Cittaro,Monika Bozek,Sameena Iqbal,Janet Matthews,David Wrench,Jacek Marzec,Kiran Tawana,Nikolay Popov,Ciaran O'Riain,Derville O’Shea,Emanuela Carlotti,Andrew Davies,Charles H. Lawrie,András Matolcsy,Maria Calaminici,Andrew Norton,Richard J. Byers,Charles A. Mein,Elia Stupka,T. Andrew Lister,Georg Lenz,Silvia Montoto,John G. Gribben,Yuhong Fan,Rudolf Grosschedl,Claude Chelala,Jude Fitzgibbon +33 more
TL;DR: This study provides new insights into the genetic basis of follicular lymphoma and the clonal dynamics of transformation and suggests that personalizing therapies to target key genetic alterations in the CPC represents an attractive therapeutic strategy.