M
Miguel Fernández-Arquero
Researcher at Hospital Clínico San Carlos
Publications - 133
Citations - 5200
Miguel Fernández-Arquero is an academic researcher from Hospital Clínico San Carlos. The author has contributed to research in topics: Single-nucleotide polymorphism & Haplotype. The author has an hindex of 36, co-authored 121 publications receiving 4856 citations. Previous affiliations of Miguel Fernández-Arquero include Complutense University of Madrid.
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Journal ArticleDOI
Multiple common variants for celiac disease influencing immune gene expression
Patrick Dubois,Gosia Trynka,Lude Franke,Lude Franke,Karen A. Hunt,Jihane Romanos,Alessandra Curtotti,Alexandra Zhernakova,Graham A. Heap,Róza Ádány,Arpo Aromaa,Maria Teresa Bardella,Leonard H. van den Berg,Nicholas A. Bockett,Emilio G. de la Concha,Bárbara Dema,Rudolf S N Fehrmann,Miguel Fernández-Arquero,Szilvia Fiatal,Szilvia Fiatal,Elvira Grandone,Peter M. Green,Harry J.M. Groen,Rhian Gwilliam,Roderick H. J. Houwen,Sarah E. Hunt,Katri Kaukinen,Dermot Kelleher,Ilma Rita Korponay-Szabó,Kalle Kurppa,Padraic MacMathuna,Markku Mäki,Maria Cristina Mazzilli,Owen T. McCann,M. Luisa Mearin,Charles A. Mein,Muddassar M. Mirza,Vanisha Mistry,Barbara Mora,Katherine I. Morley,Chris J. J. Mulder,Joseph A. Murray,Concepción Núñez,Elvira Oosterom,Roel A. Ophoff,Roel A. Ophoff,Isabel Polanco,Leena Peltonen,Leena Peltonen,Mathieu Platteel,Anna Rybak,Veikko Salomaa,Joachim J. Schweizer,Maria Pia Sperandeo,Greetje J. Tack,Graham Turner,Jan H. Veldink,Wieke H. M. Verbeek,Rinse K. Weersma,Victorien M. Wolters,Elena Urcelay,Bożena Cukrowska,Luigi Greco,Susan L. Neuhausen,Ross McManus,Donatella Barisani,Panos Deloukas,Jeffrey C. Barrett,Päivi Saavalainen,Cisca Wijmenga,David A. van Heel +70 more
TL;DR: This article performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects, and genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls.
Multiple common variants for celiac disease influencing immune gene expression
Patrick Dubois,Gosia Trynka,Lude Franke,Lude Franke,Karen A. Hunt,Jihane Romanos,Alessandra Curtotti,Alexandra Zhernakova,Graham A. Heap,Róza Ádány,Arpo Aromaa,Maria Teresa Bardella,Leonard H. van den Berg,Nicholas A. Bockett,Emilio G. de la Concha,Bárbara Dema,Rudolf S N Fehrmann,Miguel Fernández-Arquero,Szilvia Fiatal,Szilvia Fiatal,Elvira Grandone,Peter M. Green,Harry J.M. Groen,Rhian Gwilliam,Roderick H. J. Houwen,Sarah E. Hunt,Katri Kaukinen,Dermot Kelleher,Ilma Rita Korponay-Szabó,Kalle Kurppa,Padraic MacMathuna,Markku Mäki,Maria Cristina Mazzilli,Owen T. McCann,M. Luisa Mearin,Charles A. Mein,Muddassar M. Mirza,Vanisha Mistry,Barbara Mora,Katherine I. Morley,Chris J. J. Mulder,Joseph A. Murray,Concepción Núñez,Elvira Oosterom,Roel A. Ophoff,Roel A. Ophoff,Isabel Polanco,Leena Peltonen,Leena Peltonen,Mathieu Platteel,Anna Rybak,Veikko Salomaa,Joachim J. Schweizer,Maria Pia Sperandeo,Greetje J. Tack,Graham Turner,Jan H. Veldink,Wieke H. M. Verbeek,Rinse K. Weersma,Victorien M. Wolters,Elena Urcelay,Bożena Cukrowska,Luigi Greco,Susan L. Neuhausen,Ross McManus,Donatella Barisani,Panos Deloukas,Jeffrey C. Barrett,Päivi Saavalainen,Cisca Wijmenga,David A. van Heel +70 more
TL;DR: Variants from 13 new regions reached genome-wide significance and most contain genes with immune functions, with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection.
Journal ArticleDOI
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
Ricardo C. Ferreira,Qiang Pan-Hammarström,Robert R. Graham,Vesela Gateva,Gumersindo Fontán,Annette Lee,Ward Ortmann,Elena Urcelay,Miguel Fernández-Arquero,Concepción Núñez,Gudmundur H. Jorgensen,Bjorn R. Ludviksson,Sinikka Koskinen,Katri Haimila,Hilary Clark,Lars Klareskog,Peter K. Gregersen,Timothy W. Behrens,Lennart Hammarström +18 more
TL;DR: The hypothesis that autoimmune mechanisms may contribute to the pathogenesis of IgAD is supported, after a genome-wide association study in 430 affected individuals from Sweden and Iceland and 1,090 ethnically matched controls.
Journal ArticleDOI
Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.
Alfonso Martínez,Jezabel Varadé,Ana Márquez,María Carmen Cenit,L. Espino,Nieves Perdigones,Jose Luis Santiago,Miguel Fernández-Arquero,H. de la Calle,Rafael Arroyo,Juan Luis Mendoza,Benjamín Fernández-Gutiérrez,E G de la Concha,Elena Urcelay +13 more
TL;DR: The STAT4 gene is emerging as a novel common risk factor for diverse complex diseases, including inflammatory bowel disease, Crohn's disease and ulcerative colitis and type 1 diabetes mellitus.
Journal ArticleDOI
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population
Alfonso Martínez,Antonio Valdivia,Dora Pascual-Salcedo,J. Ramón Lamas,Miguel Fernández-Arquero,Alejandro Balsa,Benjamín Fernández-Gutiérrez,E G de la Concha,Elena Urcelay +8 more
TL;DR: The results of this group and from the British and French studies strongly suggest that polymorphisms of the PADI4 gene do not play a role in susceptibility to RA in European populations.