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Dexin Li
Researcher at Chinese Center for Disease Control and Prevention
Publications - Â 136
Citations - Â 9837
Dexin Li is an academic researcher from Chinese Center for Disease Control and Prevention. The author has contributed to research in topics: Virus & Antibody. The author has an hindex of 39, co-authored 128 publications receiving 8747 citations. Previous affiliations of Dexin Li include Prevention Institute.
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Journal ArticleDOI
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Fever with thrombocytopenia associated with a novel bunyavirus in China.
Xue Jie Yu,Mi Fang Liang,Shou Yin Zhang,Yan Liu,Jiandong Li,Yu Lan Sun,Lihong Zhang,Quan Fu Zhang,Vsevolod L. Popov,Chuan Li,Jing Qu,Qun Li,Yan Ping Zhang,Rong Hai,Wei Wu,Qin Wang,Fa Xian Zhan,Xian Jun Wang,Biao Kan,Shi Wen Wang,Kang Lin Wan,Huai Qi Jing,Jin Xin Lu,Wen Wu Yin,Hang Zhou,Xu Hua Guan,Jia Fa Liu,Zhen Qiang Bi,Guohua Liu,Jun Ren,Hua Wang,Zhuo Zhao,Jing Dong Song,Jin Rong He,Tao Wan,Jing Shan Zhang,Xiu Ping Fu,Li Na Sun,Xiao-Ping Dong,Zi Jian Feng,Wei Zhong Yang,Tao Hong,Yu Zhang,David H. Walker,Yu Wang,Dexin Li +45 more
TL;DR: A novel phlebovirus was identified in patients with a life-threatening illness associated with fever and thrombocytopenia in China using enzyme-linked immunosorbent assay, indirect immunofluorescence assay, and neutralization testing to analyze the level of virus-specific antibody in patients' serum samples.
Fever with thrombocytopenia associated with a novel bunyavirus in China
Abstract: BACKGROUND
Heightened surveillance of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause. Infection with Anaplasma phagocytophilum has been suggested as a cause, but the pathogen has not been detected in most patients on laboratory testing.
METHODS
We obtained blood samples from patients with the case definition of SFTS in six provinces in China. The blood samples were used to isolate the causal pathogen by inoculation of cell culture and for detection of viral RNA on polymerase-chain-reaction assay. The pathogen was characterized on electron microscopy and nucleic acid sequencing. We used enzyme-linked immunosorbent assay, indirect immunofluorescence assay, and neutralization testing to analyze the level of virus-specific antibody in patients' serum samples.
RESULTS
We isolated a novel virus, designated SFTS bunyavirus, from patients who presented with fever, thrombocytopenia, leukocytopenia, and multiorgan dysfunction. RNA sequence analysis revealed that the virus was a newly identified member of the genus phlebovirus in the Bunyaviridae family. Electron-microscopical examination revealed virions with the morphologic characteristics of a bunyavirus. The presence of the virus was confirmed in 171 patients with SFTS from six provinces by detection of viral RNA, specific antibodies to the virus in blood, or both. Serologic assays showed a virus-specific immune response in all 35 pairs of serum samples collected from patients during the acute and convalescent phases of the illness.
CONCLUSIONS
A novel phlebovirus was identified in patients with a life-threatening illness associated with fever and thrombocytopenia in China. (Funded by the China Mega-Project for Infectious Diseases and others.).
Journal ArticleDOI
Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study
Haiying Chen,Hui Yuan,Rongbao Gao,Jinxiang Zhang,Dayan Wang,Ying Xiong,Guoyin Fan,Fan Yang,Xiaodan Li,Jianfang Zhou,Shumei Zou,Lei Yang,Tao Chen,Libo Dong,Hong Bo,Xiang Zhao,Ye Zhang,Yu Lan,Tian Bai,Jie Dong,Qun Li,Shiwen Wang,Yanping Zhang,Hui Li,Tian Gong,Yong Shi,Xiansheng Ni,Jianxiong Li,Jun Zhou,Jiyi Fan,Jingwen Wu,Xianfeng Zhou,Maohong Hu,Jianguo Wan,Weizhong Yang,Dexin Li,Guizhen Wu,Zijian Feng,George F. Gao,Yu Wang,Qi Jin,Mingbin Liu,Yuelong Shu +42 more
TL;DR: The first human infection with a novel reassortant avian influenza A H10N8 virus is reported, which was isolated from a patient from Nanchang City, China and caused human infection and could have been associated with the death of a patient.
Journal ArticleDOI
An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China.
Yan Zhang,Zhen Zhu,Weizhong Yang,Jun Ren,Xiaojuan Tan,Yu Wang,Naiying Mao,Songtao Xu,Shuangli Zhu,Aili Cui,Yong Zhang,Dongmei Yan,Qun Li,Xiao-Ping Dong,Jing Zhang,Yueping Zhao,Junfeng Wan,Zijian Feng,Junling Sun,Shiwen Wang,Dexin Li,Wenbo Xu +21 more
TL;DR: An emerging recombinant HEV71 was responsible for the HFMD outbreak in Fuyang City of China, 2008, and was confirmed as the etiological pathogen of the outbreak.