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Xiyan Li
Researcher at Chinese Center for Disease Control and Prevention
Publications - 68
Citations - 4055
Xiyan Li is an academic researcher from Chinese Center for Disease Control and Prevention. The author has contributed to research in topics: Virus & Influenza A virus subtype H5N1. The author has an hindex of 20, co-authored 61 publications receiving 3594 citations. Previous affiliations of Xiyan Li include National Health and Family Planning Commission & Centers for Disease Control and Prevention.
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Journal ArticleDOI
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Global circulation patterns of seasonal influenza viruses vary with antigenic drift.
Trevor Bedford,Steven Riley,Ian G. Barr,Shobha Broor,Mandeep S. Chadha,Nancy J. Cox,Rodney S. Daniels,C. Palani Gunasekaran,Aeron C. Hurt,Anne Kelso,Alexander Klimov,Nicola S. Lewis,Xiyan Li,John W. McCauley,Takato Odagiri,Varsha Potdar,Andrew Rambaut,Yuelong Shu,Eugene Skepner,Derek J. Smith,Marc A. Suchard,Masato Tashiro,Dayan Wang,Xiyan Xu,Philippe Lemey,Colin A. Russell +25 more
TL;DR: Detailed epidemic models support differences in age of infection, combined with the less frequent travel of children, as probable drivers of the differences in the patterns of global circulation, suggesting a complex interaction between virus evolution, epidemiology, and human behaviour.
Journal ArticleDOI
Biological features of novel avian influenza A (H7N9) virus
Jiangfang Zhou,Dayan Wang,Rongbao Gao,Baihui Zhao,Jingdong Song,Xian Qi,Yanjun Zhang,Yonglin Shi,Lei Yang,Wenfei Zhu,Tian Bai,Kun Qin,Yu Lan,Shumei Zou,Junfeng Guo,Jie Dong,Libo Dong,Ye Zhang,Hejiang Wei,Xiaodan Li,Jian Lu,Liqi Liu,Xiang Zhao,Xiyan Li,Weijuan Huang,Le-ying Wen,Hong Bo,Li Xin,Y. Chen,Cuilin Xu,Yuquan Pei,Yue Yang,Xiaodong Zhang,Shiwen Wang,Zijian Feng,Jun Han,Weizhong Yang,George F. Gao,Guizhen Wu,Dexin Li,Yu Wang,Yuelong Shu +41 more
TL;DR: It is shown that the emerging H7N9 avian influenza virus poses a potentially high risk to humans, and current seasonal vaccination could not provide protection.
Journal ArticleDOI
Genesis and Spread of Newly Emerged Highly Pathogenic H7N9 Avian Viruses in Mainland China.
Lei Yang,Wenfei Zhu,Xiyan Li,Minmei Chen,Jie Wu,Pengbo Yu,Shun-Xiang Qi,Yiwei Huang,Weixian Shi,Jie Dong,Xiang Zhao,Weijuan Huang,Zi Li,Xiaoxu Zeng,Hong Bo,Tao Chen,Wenbing Chen,Jia Liu,Ye Zhang,Zhenli Liang,Wei Shi,Yuelong Shu,Yuelong Shu,Dayan Wang +23 more
TL;DR: This study comprehensively analyzed the sequences of HPAI H7N9 viruses from 28 human and 21 environmental samples covering eight provinces in China that were taken from November 2016 to June 2017 and showed that the ancestor virus of the HPAi H7n9 viruses originated in the Yangtze River Delta region.
Journal ArticleDOI
Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
Wenfei Zhu,Jianfang Zhou,Zi Li,Lei Yang,Xiyan Li,Weijuan Huang,Sumei Zou,Wenbing Chen,Hejiang Wei,Jing Tang,Liqi Liu,Jie Dong,Dayan Wang,Yuelong Shu +13 more
TL;DR: The insertion of four amino acids at the haemagglutinin cleavage site enabled trypsin-independent infectivity of this virus and the neuraminidase substitution R292K conferred a multidrug resistance phenotype.