Diane J. Aum

TL;DR: It is emphasized that each individual glioblastoma should begin to be an ensemble of molecularly distinct subclones that reflect a spectrum of dynamic cell states.

TL;DR: Clinical evidence that high expression of NAMPT, the rate-limiting step in NAD+ biosynthesis, in glioblastoma tumors is associated with poor overall survival in patients is provided, and a NAD+-dependent transcriptional program that governs GSC self-renewal and dictates the radiation resistance of these cells is delineated.

TL;DR: Delayed cerebral ischemia is an independent risk factor for poor outcome after aneurysmal subarachnoid hemorrhage and a role for matrix metalloproteinase‐9 in early brain injury after SAH is unclear.

TL;DR: SIRT1 mediates hypoxic preconditioning-induced protection against neurovascular dysfunction after SAH, and Resveratrol mimics this neurov vascular protection, at least in part, via SIRT1.

TL;DR: In this article, the authors found that hypoxic postconditioning (8% O2 for 2 hours) initiated 3 hours after subarachnoid hemorrhage (SAH) provides strong protection against cerebral vasospasm, microvessel thrombi, and neurological deficits.