D
Dick B. Janssen
Researcher at University of Groningen
Publications - 387
Citations - 19823
Dick B. Janssen is an academic researcher from University of Groningen. The author has contributed to research in topics: Haloalkane dehalogenase & Dehalogenase. The author has an hindex of 76, co-authored 374 publications receiving 18485 citations. Previous affiliations of Dick B. Janssen include Radboud University Nijmegen & Codexis.
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Journal ArticleDOI
Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines.
Qinglong Meng,Carlos Ramírez-Palacios,Nikolas Capra,Mattijs E. Hooghwinkel,Sebastian Thallmair,Sebastian Thallmair,Henriëtte J. Rozeboom,Andy-Mark W. H. Thunnissen,Hein J. Wijma,Siewert J. Marrink,Dick B. Janssen +10 more
TL;DR: In this article, a computational design strategy using computational design to expand the substrate scope of an (S)-selective ω-TA from Pseudomonas jessenii (PjTA-R6) toward the production of bulky amines was explored.
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Transformation of carbon tetrachloride in an anaerobic packed-bed reactor without addition of another electron donor
TL;DR: Transformation of carbon tetrachloride in the absence of an added electron donor suggests thatcarbon tetrACHloride itself is the source of energy for the biological reaction observed, and possibly the sources of carbon for cell growth.
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A single point mutation enhances hydroxynitrile synthesis by halohydrin dehalogenase.
M. Schallmey,Peter A. Jekel,Lixia Tang,Lixia Tang,Maja Majerić Elenkov,Hans Wolfgang Höffken,Bernhard Hauer,Dick B. Janssen +7 more
TL;DR: Structural analysis revealed that the anion-binding site of the mutant enzyme remained unaltered, showing that the enhanced activity is due to altered interactions with the substrate oxygen rather than changes in the nucleophile binding site.
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Sequence analysis of the upstream region of dhlB, the gene encoding haloalkanoic acid dehalogenase of Xanthobacter autotrophicus GJ10
TL;DR: The genetic organization of thedhlB region suggested that the expression of dhlC and dhlB was controlled by the product ofdhlR and σ54 which may explain the observed overexpression of the haloalkanoic acid dehalogenase under starvation conditions.
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Biocatalytic Conversion of Epoxides
Erik J. de Vries,Dick B. Janssen +1 more
TL;DR: In this paper, the emerging new possibilities for enanti-selective biocatalytic conversion of epoxides suggests that their importance in green chemistry will grow, which is a good sign for green chemistry.