The mitochondrial respiratory chain has the crucial function of supplying the cell with energy in the form of ATP. Mutations affecting this chain can arise in mitochondrial or nuclear DNA and cause diseases known as mitochondrial encephalomyopathies. Because the rules of inheritance of mitochondrial and nuclear DNA differ considerably, these brain–muscle syndromes often have unpredictable clinical and genetic features.

https://www.nejm.org/doi/pdf/10.1056/NEJMra022567

Mitochondrial respiratory-chain diseases

https://archive-ouverte.unige.ch/unige:20261/ATTACHMENT01

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

Enzymes of triacylglycerol synthesis and their regulation

The cell wall of Saccharomyces cerevisiae is an elastic structure that provides osmotic and physical protection and determines the shape of the cell. The inner layer of the wall is largely responsible for the mechanical strength of the wall and also provides the attachment sites for the proteins that form the outer layer of the wall. Here we find among others the sexual agglutinins and the flocculins. The outer protein layer also limits the permeability of the cell wall, thus shielding the plasma membrane from attack by foreign enzymes and membrane-perturbing compounds. The main features of the molecular organization of the yeast cell wall are now known. Importantly, the molecular composition and organization of the cell wall may vary considerably. For example, the incorporation of many cell wall proteins is temporally and spatially controlled and depends strongly on environmental conditions. Similarly, the formation of specific cell wall protein–polysaccharide complexes is strongly affected by external conditions. This points to a tight regulation of cell wall construction. Indeed, all five mitogen-activated protein kinase pathways in bakers’ yeast affect the cell wall, and additional cell wall-related signaling routes have been identified. Finally, some potential targets for new antifungal compounds related to cell wall construction are discussed.

Dynamics of cell wall structure in Saccharomyces cerevisiae.

The biosynthesis and functional role of cardiolipin.

Cell cycle control of yeast filamentous growth.

Quantitative determination of phenolic compounds by UHPLC-UV–MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads

Diego Rua

Papers

The biosynthesis and functional role of cardiolipin.

Cell cycle control of yeast filamentous growth.

Quantitative determination of phenolic compounds by UHPLC-UV–MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads

Cardiolipin Synthase Is Associated with a Large Complex in Yeast Mitochondria

A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.