Showing papers by "Dinesh K. Patel published in 2022"

Liquid Crystal Elastomer with Integrated Soft Thermoelectrics for Shape Memory Actuation and Energy Harvesting

Abstract: Liquid crystal elastomers (LCEs) have attracted tremendous interest as actuators for soft robotics due to their mechanical and shape memory properties. However, LCE actuators typically respond to thermal stimulation through active Joule heating and passive cooling, which make them difficult to control. In this work, LCEs are combined with soft, stretchable thermoelectrics to create transducers capable of electrically controlled actuation, active cooling, and thermal‐to‐electrical energy conversion. The thermoelectric layers are composed of semiconductors embedded within a 3D printed elastomer matrix and wired together with eutectic gallium–indium (EGaIn) liquid metal interconnects. This layer is covered on both sides with LCE, which alternately heats and cools to achieve cyclical bending actuation in response to voltage‐controlled Peltier activation. Moreover, the thermoelectric layer can harvest energy from thermal gradients between the two LCE layers through the Seebeck effect, allowing for regenerative energy harvesting. As demonstrations, first, closed‐loop control of the transducer is performed to rapidly track a changing actuator position. Second, a soft robotic walker that is capable of walking toward a heat source and harvesting energy is introduced. Lastly, phototropic‐inspired autonomous deflection of the limbs toward a heat source is shown, demonstrating an additional method to increase energy recuperation efficiency for soft systems.

A Review of Properties of Nanocellulose, Its Synthesis, and Potential in Biomedical Applications

Abstract: Cellulose is the most venerable and essential natural polymer on the planet and is drawing greater attention in the form of nanocellulose, considered an innovative and influential material in the biomedical field. Because of its exceptional physicochemical characteristics, biodegradability, biocompatibility, and high mechanical strength, nanocellulose attracts considerable scientific attention. Plants, algae, and microorganisms are some of the familiar sources of nanocellulose and are usually grouped as cellulose nanocrystal (CNC), cellulose nanofibril (CNF), and bacterial nanocellulose (BNC). The current review briefly highlights nanocellulose classification and its attractive properties. Further functionalization or chemical modifications enhance the effectiveness and biodegradability of nanocellulose. Nanocellulose-based composites, printing methods, and their potential applications in the biomedical field have also been introduced herein. Finally, the study is summarized with future prospects and challenges associated with the nanocellulose-based materials to promote studies resolving the current issues related to nanocellulose for tissue engineering applications.

Biological importance of a biflavonoids 'bilobetin' in the medicine: Medicinal importance, pharmacological activities and analytical aspects.

Abstract: BACKGROUND Flavonoid class phytochemicals are natural compounds found to be present in different medicinal plants, vegetables and fruits. Ginkgo biloba contain significant amounts of bioflavonoid 'bilobetin'. Bilobetin is an active phytochemical used for treatment of human health complications due to its medicinal properties and therapeutic benefit. The purpose of this work is to collect and reviewed scientific data of bilobetin from different literature sources; highlight their biological properties, pharmacological activities and analytical aspects. METHODS Health beneficial aspects of bilobetin have been investigated in the present work through scientific data analysis. PubMed, Google Scholar, Google, Scopus etc. has been searched in the present work in order to collect scientific information of bilobetin in the present work. Medicinal importance and therapeutic benefit of bilobetin has been searched in the present work through these databases in the present work. Detailed pharmacological activities of bilobetin have reviewed in the present work through literature data analysis of various scientific research works. However, analytical data were also collected and reviewed in the present work. RESULTS Literature data analysis of bilobetin in the present work revealed the medicinal properties and therapeutic potential of bilobetin mainly due to its anti-fungal, anti-inflammatory, anti-oxidant, anti-hyperlipidemic, and anti-proliferative activities. Literature data analysis revealed the effectiveness of bilobetin on osteoporosis, glucose metabolism, adipocytes, SARS CoV-2, Influenza A virus and human thrombin. Scientific data also revealed the importance of different analytical techniques for the isolation, separation, identification, and quantification of bilobetin. CONCLUSION Scientific data analysis revealed biological importance and pharmacological activities of bilobetin in the health sectors.

Bioengineered Lab-Grown Meat-like Constructs through 3D Bioprinting of Antioxidative Protein Hydrolysates.

Abstract: Lab-grown bovine meat analogues are emerging alternatives to animal sacrifices for cultured meat production. The most challenging aspect of the production process is the rapid proliferation of cells and establishment of the desired 3D structure for mass production. In this study, we developed a direct ink writing-based 3D-bioprinted meat culture platform composed of 6% (w/v) alginate and 4% (w/v) gelatin (Alg/Gel)-based hydrogel scaffolds supplemented with naturally derived protein hydrolysates (PHs; 10%) from highly nutritive plants (soybean, pigeon pea, and wheat), and some selected edible insects (beetles, crickets, and mealworms) on in vitro proliferation of bovine myosatellite cells (bMSCs) extracted from fresh meat samples. The developed bioink exhibited excellent shear-thinning behavior (n < 1) and mechanical stability during 3D bioprinting. Commercial proteases (Alcalase, Neutrase, and Flavourzyme) were used for protein hydrolysis. The resulting hydrolysates exhibited lower-molecular-weight bands (12-50 kDa) than those of crude isolates (55-160 kDa), as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The degree of hydrolysis was higher in the presence of Alcalase for both plant (34%) and insect (62%) PHs than other enzymes. The 3D-printed hydrogel scaffolds displayed excellent bioactivity and stability after 7 days of incubation. The developed prototype structure (pepperoni meat, 20 × 20 × 5 mm) provided a highly stable, nutritious, and mechanically strong structure that supported the rapid proliferation of myoblasts in a low-serum environment during the entire culture period. The 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay enhanced the free radical reduction of Alcalase- and Neutrase-treated PHs. Furthermore, the bioprinted bMSCs displayed early myogenesis (desmin and Pax7) in the presence of PHs, suggesting its role in bMSC differentiation. In conclusion, we developed a 3D bioprinted and bioactive meat culture platform using Alg/Gel/PHs as a printable and edible component for the mass production of cultured meat.

Biological potential and therapeutic benefit of Chrysosplenetin: An Applications of polymethoxylated flavonoid in medicine from natural sources

Abstract: Herbal medicines contain single herb or many herbal ingredients derived from the plant and their byproducts. The beneficial effects of medicinal plants in the healthcare system are mainly due to the presence of secondary metabolites which have numerous biological applications in medicine. Chrysosplenetin is a polymethoxylated flavonoid class phytochemical found to be present in Artemisia annua L. and Dracocephalum heterophyllum Benth. Scientific research data of chrysosplenetin has been collected from various literature databases in the present work and analyzed for their medicinal properties and pharmacological activities. Medicinal importance and pharmacological activity data of chrysosplenetin has been collected from Google, Science Direct, PubMed, and Scopus and analyzed in the present work to know the therapeutic benefit of chrysosplenetin. However, the analytical data of chrysosplenetin has been also collected and analyzed in the present work to know the importance of modern analytical techniques in the separation, isolation, and identification of chrysosplenetin. Scientific data analysis of collected research work from various literature databases revealed the biological importance of chrysosplenetin in medicine. Pharmacological data of chrysosplenetin revealed the anti-malarial, antiproliferative, and antibacterial effect of chrysosplenetin. Chrysosplenetin has a significant effect on bone loss, enterovirus 71, trichomoniasis, tyrosinase enzyme, multidrug resistance, inflammatory, and neurological disorders. Pharmacokinetic parameters of chrysosplenetin have been also studied in the present work. Literature data analysis signified the potential role of different analytical techniques in medicine for their isolation, separation, and quantification. Scientific data analysis of the collected data of chrysosplenetin in the present work signified the therapeutic benefit of chrysosplenetin in medicine for the treatment of numerous diseases and associated complications.

Biological importance and therapeutic potential of trilobatin in the management of human disorders and associated secondary complications

Abstract: Herbal medicine, including some pure phytochemicals has been used in medicine due to their health benefit and pharmacological activities. Lithocarpus polystachyus Rehd. has been consumed as a source of dihydrochalcones. Approximatively 200 dihydrochalcones are known to be found in over 30 plant including Pieris japonica, Piper elongatum, Lindera lucida, Fragaria ananassa, Lithocarpus polystachyus, and Lactuca sativa. Biological potential of trilobatin on human health have been investigated in the present work, in order to know the health beneficial aspects of dihydrochalcones in medicine. Present work described the medicinal importance of trilobatin in the scientific field with their potential molecular mechanisms. Pharmacological activities data of trilobatin have been collected from different scientific databases including Google, Google Scholar, Science Direct and PubMed and analyzed in the present work. Scientific data of analytical techniques used for the separation and identification of trilobatin has been also discussed in the present work. Trilobatin is a natural sweetener which is the main dihydrochalcones in sweet tea. Trilobatin exhibit plenty of health benefits including anti-oxidant, anti-inflammatory, cardioprotective, hepatoprotective, anti-diabetic, and anti-cancer effects. Scientific data analysis revealed the biological importance and therapeutic benefit of trilobatin in medicine, as it have Anti-Alzheimer's, neuroprotective, antiobesity, longevity-enhancing effect, anti-inflammatory and anti-oxidant activity. Further, its effectiveness on ischemic stroke, osteoporosis, human hepatoblastoma cells, HIV-1 entry inhibitor and tyrosinase inhibitors have been also discussed in the present work. Moreover, analytical data signified the effectiveness of different analytical methods for separation, isolation and identification of trilobatin in medicine. Present work signified the biological importance and therapeutic potential of trilobatin in medicine.

Medicinal importance, pharmacological activities and analytical aspects of a flavonoid glycoside 'nicotiflorin' in the medicine.

Abstract: BACKGROUND Herbal products have been derived from different natural sources, mainly used as a source of food material and medicine in the health sectors since very ancient time. Herbal products have gained popularity in the modern medicine due to its health beneficial properties and pharmacological activities. Flavonoids are an important class of secondary metabolites found to be present in the medicinal plants and their derived products. Flavonoids has been known for their anti-allergic, anti-bacterial, anti-diabetic, anti-inflammatory, anti-viral, anti-proliferative, anti-mutagenic, anti-thrombotic, anti-carcinogenic, anti-oxidant and hepatoprotective activities in the medicine. Nicotiflorin is a flavonoidal class phytochemical, found to be present in medicinal plants, including Traditional Chinese medicine. METHODS Scientific data of medicinal importance and pharmacological activities of nicotiflorin have been collected and analyzed in the present work in order to know the therapeutic importance of nicotiflorin in the medicine. Scientific data have been collected from Google, Google Scholar, Science Direct, PubMed and Scopus and analyzed in the present work. Analytical techniques data of separation, isolation and identification of nicotiflorin have also been collected and presented in the present work. Further biological importance of flavonoidal class phytochemicals was also discussed in the present work to understand the biological importance of nicotiflorin in the medicine as it's belongs to the flavonoid class. RESULTS Scientific data analysis revealed the therapeutic importance and pharmacological activities of nicotiflorin. Nicotiflorin has significant biological potential against coronavirus, ischemia, renal impairment, hepatic complication, memory dysfunction and myocardial Infarction. The biological potential of nicotiflorin against α-glucosidase and α-amylase enzymes, multiple myeloma cells and insulin secretion has been also discussed in the present work. Analytical data revealed the significance of modern analytical tools in the medicine for the isolation, separation and quantification of nicotiflorin. CONCLUSION Scientific data analysis of different research work revealed the biological importance and therapeutic potential of nicotiflorin in medicine.

Grandisin and its Therapeutic potential and Pharmacological Activities: a review

Abstract: • Plant derived products and phytoconstituents have been used in medicine for the treatment of human disorders and associated secondary complication since a very early age. Phytoconstituents have numerous biological potential and therapeutic benefits in medicine. Lignans are a kind of non-flavonoids polyphenols which can bind to the estrogen receptors and function as phytoestrogens. Lignans have anti-tumor, antioxidant, and other pharmacological activities. • Scientific data of grandisin have been collected from different databases in the present work and analyzed in order to know the biological importance and therapeutic benefit of grandisin in medicine. Scientific data have been collected from Science Direct, Google, Google Scholar, PubMed, and Scopus using term herbal medicines, traditional Chinese medicine, lignans, and grandisin. Detailed pharmacological activities of grandisin have been analyzed in the present investigation through scientific data analysis of different scientific research work. However, analytical data of grandisin have been also collected and analyzed in the present investigation. • Grandisin is an important class of tetrahydrofuran neolignan found to be present in Virola surinamensis , and Piper solmsianum . Grandisin have high trypanocidal activity against the tripomastigote forms of Trypanosoma cruzi . Scientific study signified the biological potential of grandisin in medicine for their anti-leishmanial, chemoprotective, cytotoxicity, anti-angiogenic, anti-nociceptive, anti-inflammatory, and larvicidal activity. However, it's potential for vascular diseases, biotransformation and metabolism have been also discussed in the present work. Analytical data revealed the importance of various analytical techniques for the separation, isolation and identification of grandisin from various medicinal plants, including Aglaia leptantha, and Cryptocarya crassinervia . Plant derived products and phytoconstituents have been used in medicine for the treatment of human disorders and associated secondary complication since a very early age. Phytoconstituents have numerous biological potential and therapeutic benefits in medicine. Lignans are a kind of non-flavonoids polyphenols which can bind to the estrogen receptors and function as phytoestrogens. Lignans have anti-tumor, antioxidant, and other pharmacological activities. Scientific data of grandisin have been collected from different databases in the present work and analyzed in order to know the biological importance and therapeutic benefit of grandisin in medicine. Scientific data have been collected from Science Direct, Google, Google Scholar, PubMed, and Scopus using term herbal medicines, traditional Chinese medicine, lignans, and grandisin. Detailed pharmacological activities of grandisin have been analyzed in the present investigation through scientific data analysis of different scientific research work. However, analytical data of grandisin have been also collected and analyzed in the present investigation. Grandisin is an important class of tetrahydrofuran neolignan found to be present in Virola surinamensis , and Piper solmsianum . Grandisin have high trypanocidal activity against the tripomastigote forms of Trypanosoma cruzi . Scientific study signified the biological potential of grandisin in medicine for their anti-leishmanial, chemoprotective, cytotoxicity, anti-angiogenic, anti-nociceptive, anti-inflammatory, and larvicidal activity. However, it's potential for vascular diseases, biotransformation and metabolism have been also discussed in the present work. Analytical data revealed the importance of various analytical techniques for the separation, isolation and identification of grandisin from various medicinal plants, including Aglaia leptantha, and Cryptocarya crassinervia .

Health beneficial aspect and therapeutic potential of cirsimaritin in the medicine for the treatment of human health complications

Abstract: Herbal plants have been used in medicine for the treatment of numerous human health complications. Plant derived product, including extract, botanicals and preparations have been used in medicine and other allied health sectors since a very early age and available in the market for several decades. Flavonoids have been a well-known class of phytochemicals in medicine due to their anti-oxidant, anti-cancer, anti-inflammatory, anti-bacterial and hepatoprotective potential. In order to know the medicinal importance and therapeutic benefit of cirsimaritin in medicine, here in the present investigation, scientific research datas have been collected from various literature data sources and analyzed. Science Direct, Google, Google Scholar, PubMed and Scopus database have been used in the present investigation to search the scientific information of cirsimaritin. Detailed pharmacological activities of cirsimaritin have been analyzed in the present investigation through scientific research data analysis to know biological potential of cirsimaritin. However, for the standardization of plant material, numerous analytical techniques have been developed in the scientific field, and analytical data of cirsimaritin have been collected and analyzed in the present investigation through various literature databases Cirsimaritin also called 4',5-Dihydroxy-6,7-dimethoxyflavone is a flavonoidal class phytochemical, found to be present in the medicinal plant. Cirsimaritin has been used in medicine for the treatment of numerous human health complications. From the analysis of scientific data in medicine, it was found that cirsimaritin has numerous health beneficial aspects in the medicine due to their vast pharmacological activities. The medicinal importance of cirsimaritin in medicine is mainly due to its anti-oxidant, anti-bacterial and anti-inflammatory activities. Further data analysis revealed the therapeutic effectiveness of cirsimaritin on breast cancer, gallbladder carcinoma, central nervous system disorders, diabetes mellitus, melanogenesis, immune responses, human erythrocytes and respiratory burst. Scientific data analysis revealed the importance of GC-MS, LC-MS, HS-SPME, FTIR, ICP-OES, MS, NMR, LC/ESI-MS/MS, HPLC, Reversed-phase HPLC and TLC techniques for the analysis of cirsimaritin in the medicine. The scientific data of present work revealed the biological importance of cirsimaritin for the treatment of human health complications, which could be used for the development of effective medicine from cirsimaritin against human disorders

Therapeutic Effectiveness of Magnolin on cancers and other Human complications

Abstract: Lignan is ubiquitous within the plant kingdom and present in almost all plants, including Magnolia fargesii Cheng. and Magnolia fargesii. Lignan has been used for the treatment of human health complications, including allergic rhinitis. Magnolin is a lignan class phytochemical abundantly present in Magnolia spp. and has been widely used as an oriental medicine to treat human disorders. Magnolin is an active furofuranoid lignans found to be present in the Magnolia biondii which exhibit anti-inflammatory, anti-cancer, anti-oxidant, and vasodilatory effect in medicine. The overview of the present work is to analyze the scientific information of magnolin, in order to provide a comprehensive insight into the preventive and therapeutic potential of magnolin in medicine. Scopus, PubMed, Science Direct and Google Scholar databases have been searched to collect all the scientific information of magnolin using the term herbal medicine, lignan, magnolin, and phytochemical. Analytical data of magnolin has also been collected and analyzed in the present work. Scientific data analysis revealed the biological importance and therapeutic potential of magnolin in medicine. Scientific data of present work revealed the therapeutic effectiveness of magnolin in medicine for the treatment of prostate cancer, ovarian cancer, lung cancer, breast cancer, hepatocellular carcinoma, colorectal cancers, inflammation, melanogenesis, nephropathy and allergic diseases. Further, its antiplasmodial activity and effect on histamine release and human liver enzymes has also been discussed in the present work. Analytical data of magnolin signified their importance in both qualitative and quantitative tools of magnolin. Present work summarized the medicinal importance and therapeutic potential of magnolin for the treatment of human disorders as preventive and therapeutic measures.

Recent Advances in 3D Printing of Photocurable Polymers: Types, Mechanism, and Tissue Engineering Application.

Abstract: The conversion of liquid resin into solid structures upon exposure to light of a specific wavelength is known as photopolymerization or photo-curable 3D printing. In recent years, photopolymerization-based 3D printing has gained enormous attention in tissue engineering for constructing highly complex and precise tissue structures. Due to the economic and environmental benefits of the biopolymers employed, photo-curable 3D printing is considered highly accurate and an alternative method for replacing damaged tissues. However, the lack of suitable bio-based photopolymers, their characterization, effective crosslinking strategies, and optimal printing conditions are hindering the extensive application and commercialization of those materials in the global market. This review highlights the present status of various photopolymers, their synthesis techniques, and optimization parameters for biomedical applications. Moreover, we also discussed a glimpse of various photopolymerization techniques that are currently employed for 3D printing. Furthurmore, we also reviewed the influence of various naturally-derived nanomaterial reinforced polymerization and their influence on printability and shape fidelity. Finally, the ultimate use of those photopolymerized hydrogel scaffolds in tissue engineering is also discussed. Taken together, we believe that photopolymerized 3D printing has a great future, whereas conventional 3D printing requires considerable sophistication, and this review will provide the readers with a comprehensive approach to the development of light-mediated 3D printing for tissue engineering applications. This article is protected by copyright. All rights reserved.

Biological activities and therapeutic potential of irigenin on gastric, lung, prostate, breast and endometrial cancer: A pharmacological and analytical aspects

Abstract: Herbal medicine has been in used in the medicine for thousands of years due to its multiple pharmacological activities against different types of human disorders. Biological effectiveness and pharmacological activities of herbal medicines is mainly due to the presence of different kinds of phytoconstituents commonly called secondary metabolites. Isoflavones are naturally present in different types of plants and food materials and most of these phytocompounds have a wide range of biological activities including anti-tumor, anti-proliferative, anti-inflammatory, anti-microbial, anti-viral, anti-oxidant, and estrogen-like activities. Irigenin isolated from the rhizome of Belamcanda chinensis and the genus Iris showed a wide range of biological activities. Due to huge biological potential and the therapeutic benefit of irigenin in the medicine, here in the present investigation, scientific research data of irigenin has been collected from different literature sources (Science Direct, Google Scholar, PubMed, Google) and analyzed in order to know the therapeutic potential of irigenin in the medicine. Pharmacological activities scientific data of irigenin have been collected from Science Direct, Google Scholar, PubMed, Google databases and analyzed in the present work. Importance of different analytical techniques for isolation and separation of irigenin has been also discussed and presented in the present work. Scientific data analysis of different research work revealed the biological importance of irigenin in the medicine. Irigenin is an O-methylated isoflavone found to be present in the Belamcanda chinensis and genus Iris. Scientific data analysis revealed the biological importance of irigenin against gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic complications, inflammation and cardiac injury. Analytical data of irigenin revealed the importance of analytical techniques for the separation, isolation and identification of irigenin from various biological samples. Scientific data analysis of different research works revealed the biological importance and therapeutic potential of irigenin in the medicine.

Wound healing and antioxidant potential of Neolamarckia cadamba in streptozotocin-nicotinamide induced diabetic rats

Abstract: Diabetic wounds are one of the most common disorders associated with a sedentary lifestyle. Diabetes also has the additional effect of delaying the healing of wounds. Neolamarckia cadamba (Rubiaceae) is a plant that is well-known for its wide range of pharmacological properties. The efficacy of the ethanolic extract of Neolamarckia cadamba (70%) in the forms of oral (200, 400 mg/Kg/day), and topical (5% and 10% w/w/day) administration was determined on first day of wound induction (day 1) and continued until the end day of the wound induction period (day 16). The wound healing process in diabetic wounds was studied by assessing the wound contraction, serum glucose levels, biochemical and enzymatic antioxidant status in both control and treatment groups. Excision wound model histology was done to confirm activity. In the ethanolic extract of Neolamarckia cadamba numerous phytocomponents were found by doing a phytochemical analysis (alkaloids, flavonoids, phenols, saponins, steroids, glycosides, tannins). The total phenolic and flavonoid content was determined to be 118.53 ± 1.36 mg/g and 106.51 ± 1.26 mg/g, respectively. In this investigation, Neolamarckia cadamba caused significant wound contraction of both forms i.e., oral (28.70%, 36.80% at doses 200, 400 mg/Kg/day) and topical (23.08%, 31.21% at doses 5%, 10% w/w/day) showed treated groups compared to the diabetic control. Additionally, oral treatment of Neolamarckia cadamba extract decreased serum glucose levels in diabetic wound rats on the 4th, 8th, 12th and 16th days, as compared to the diabetic wound control group. Moreover, biochemical and enzymatic status significantly decreased hexosamine, NO, and MDA, while increasing collagen, total protein, DNA, SOD, and CAT levels in the body. Histopathological investigations also demonstrated a dose-dependent improvement in wound healing in oral and topical treated groups by re-epithelialization, collagenation, and vascularization of damaged skin samples. The current study's findings indicate that the Neolamarckia cadamba may have potential for use in the formulation of diabetic wound healing medicines.

Therapeutic effectiveness of sinensetin against cancer and other human complications: A review of biological potential and pharmacological activities.

Abstract: BACKGROUND Plant and their active phytoproducts have been used in modern medicine and playing an important role in the health sectors since a very early age. Human beings need a considerable amount of these plant-based phytochemicals for their health. The flavonoidal class phytochemical is an important class of natural products in modern healthcare because of their different pharmacological activities and health benefits. Flavonoidal class phytochemicals have been used to treat diabetes and related secondary complications in humans. Flavonoids have anti-apoptotic, anti-hyperlipidemic, anti-inflammatory, and anti-oxidant potential in the health sectors. Sinensetin, also called 3',4',5,6,7-pentametoksiflavon is a colorless compound with a molecular weight 372.37g/mol and is found to be present in the Orthosiphon stamineus. METHODS In the present investigation, we aim to collect scientific information on sinensetin and analyze it for its biological potential and therapeutic benefits against various types of disorders and complications. Medicinal importance and pharmacological activities data have been collected and analyzed in the present work for sinensetin through literature data analysis of different research works. Google Science Direct, PubMed, Scopus, and Google Scholar were mainly searched to collect the scientific information in the present work. The present work analyzed sinensetin's biological potential, pharmacological activities, and analytical aspects. RESULTS Literature data analysis of different scientific research works revealed the biological potential of phytochemicals in medicine, including flavonoids. Sinensetin has anti-tumor, anti-inflammatory, anti-oxidant, anti-diabetic, and antibacterial activities through their testing in different in vitro and in vivo models. Sinensetin has physiological functions, including anti-oxidant, anti-inflammation, and anti-cancer potential in medicine. Scientific data analysis signified the biological importance of sinensetin against tumors, gastric cancer, colorectal cancer, breast cancer, diabetes, influenza H1N1 infection, obesity, inflammation, colitis, brain disorders, and microbial infections. Further biological potential of sinensetin on enzymes and angiogenesis has been analyzed in the present work. Sinensetin was isolated through different analytical and extraction techniques, including chromatographic techniques. CONCLUSION Literature data analysis signified sinensetin's biological potential and pharmacological activities in medicine.

Therapeutic role of columbianadin in human disorders: Medicinal importance, biological properties and analytical aspects

Abstract: Herbal medicines have been used for the treatment of human disorders and associated secondary complications since a very early age. Herbal medicines are composed with a variety of medicinal plants and their derived products. Coumarin class phytochemicals have an important role in medicine due to its anti-coagulant, anti-cancer, anti-HIV and anti-inflammatory activity. Herbal medicines have been gaining popularity in the modern system of medicine mainly due to its safety and efficacy. Columbianadin is an active phytochemical of Angelica pubescens and Heracleum candolleanum. Columbianadin have analgesic, anti-inflammatory, calcium-channel blocking properties and platelet aggregation inhibitory potential. Present work described the medicinal importance and pharmacological activities of columbianadin in medicine supported by their traditional medicinal application and pharmacological activities. Scientific data of columbianadin has been collected from PubMed, Google Scholar, Google, Scopus, and Science Direct. However, scientific data of columbianadin published in Journals, books and scientific report have also been collected in the present paper. Analytical data of columbianadin have also been described to know the significance of analytical techniques for the isolation, and identification of columbianadin. Scientific data of columbianadin signified the biological importance and therapeutic potential of columbianadin in medicine. Scientific data of columbianadin revealed their biological potential against inflammation, neuropathic pain, cancer, hepatic complications, and immune system disorders. However, biological effectiveness of columbianadin on blood-brain barrier permeability, body tissue, channels and platelet has also been discussed in the present work. Moreover, its therapeutic effectiveness against nematodes has been also summarized in this work. Analytical data for the isolation and identification of columbianadin in different samples has also been presented in this work. Present work signified the biological importance and therapeutic potential of columbianadin in medicine, which could be used for the treatment of human disorders and associated secondary complications.

Plant-Actuated Micro-Nanorobotics Platforms: Structural Designs, Functional Prospects, and Biomedical Applications.

Abstract: Plants are anatomically and physiologically different from humans and animals; however, there are several possibilities to utilize the unique structures and physiological systems of plants and adapt them to new emerging technologies through a strategic biomimetic approach. Moreover, plants provide safe and sustainable results that can potentially solve the problem of mass-producing practical materials with hazardous and toxic side effects, particularly in the biomedical field, which requires high biocompatibility. In this review, it is investigated how micro-nanostructures available in plants (e.g., nanoparticles, nanofibers and their composites, nanoporous materials, and natural micromotors) are adapted and utilized in the design of suitable materials for a micro-nanorobot platform. How plants' work on micro- and nanoscale systems (e.g., surface roughness, osmotically induced movements such as nastic and tropic, and energy conversion and harvesting) that are unique to plants, can provide functionality on the platform and become further prospective resources are examined. Furthermore, implementation across organisms and fields, which is promising for future practical applications of the plant-actuated micro-nanorobot platform, especially on biomedical applications, is discussed. Finally, the challenges following its implementation in the micro-nanorobot platform are also presented to provide advanced adaptation in the future.

Therapeutic importance and pharmacological activities of karanjin in the medicine for the treatment of Human disorders: A review through scientific data analysis

Abstract: Plant and derived herbal drugs have been used in the traditional system of medicine for the treatment of various forms of human health complications since a very early age. Commercial products prepared from natural herbs have been always valuable for the society in the form of health supplement to medicament. In the ancient time, herbal products were mainly prepared from plants and their derived phytochemical. Plants contain a rich source of pure phytochemical called secondary metabolite and examples are flavonoids, glycosides, tannins and terpenoids etc. Plants and their parts including fruits, flowers, vegetables etc. are the best source of Flavonoid class phytochemicals. Present work summarized the scientific information of karanjin for their health beneficial aspects and pharmacological activities including its analytical aspects. In the present investigation, scientific data of karanjin have been collected from various scientific databases such as Google, Goggle Scholar, Science Direct and PubMed and analyzed to know the health beneficial aspects of karanjin in the medicine. Further pharmacological activity data has been collected and analyzed in the present work to know their biological potential in the medicine. Analytical methods used for the separation, isolation, and identification of karanjin for the standardization of different natural products have been also discussed in the present work. Scientific data analysis signified the biological importance of Flavonoid class phytochemicals in the medicine as they are well known for their anti-ischemic, vasodilatory, anti-bacterial, anti-inflammatory, anti-oxidant, anti-viral, and anti-cancer activities. Scientific data analysis revealed the presences of karanjin in numerous medicinal plants such as Fordia cauliflora, Lonchocarpus latifolius, Millettia pinnata, Millettia pubinervis, Pongamia pinnata, and Tephrosia purpurea. Pharmacological activity data revealed the biological potential of karanjin against cancerous disorders, glucose metabolism abnormalities, gastrointestinal disorders, arthritis, inflammatory disorders, colitis, psoriasis and brain related disorders. However, analytical data signified the importance of RP-HPLC, TLC, HPTLC, UPLC-ESI-MS/MS and HSCCC techniques in the medicine for the quantification of karanjin in different samples. Presented information about karanjin in this review paper will be beneficial to the scientific peoples of the world to know the health beneficial aspects of karanjin in the medicine.

Medicinal Importance, Pharmacological Activities and Analytical Aspects of Engeletin in the Medicine: Therapeutic Benefit through Scientific Data Analysis.

Abstract: BACKGROUND Flavonoidal class phytocompounds have been used in the medicine for the treatment of numerous kinds of human health complications. Flavonoidal class phytocompounds have health beneficial aspects in medicine mainly due to its anti-microbial, anti-diabetic, anti-inflammatory, anti-cancer and anti-carcinogenic activities. Flavonoidal class phytocompounds have been well investigated in the scientific field for their health beneficial aspects and pharmacological activities against various forms of human complications. Engeletin is a pure flavanonol class glycosidal phytocompounds found to be present in the skin of white grapes and white wine. Engeletin has been reported to have numerous pharmacological activities in the scientific fields. METHODS In order to know the health beneficial aspects of engeletin in the medicine, scientific research work data have been collected from different literature sources and analyzed in the present work. Present work summarizes the important findings of engeletin from scientific research works with respects to medicinal uses, pharmacological activities and analytical aspects. All the scientific data of the present work have been collected from different search engines including PubMed, Google, Scopus, Science Direct and Google Scholar. RESULTS Literature data analysis of different scientific research works revealed the biological importance and therapeutic benefit of engeletin in the medicine. Engeletin is a flavanonol glycoside class phytochemical which has attracted human attention due to its anti-inflammatory and antitumor properties. Literature data analysis revealed that engeletin could inhibit the occurrence of cervical cancer and delay the development of liver damage and lung cancer in the mice. Engeletin was found to inhibit LPS-induced endometritis in mice through inhibiting the inflammatory response. Pharmacological data analysis revealed the therapeutic importance of engeletin against inflammatory disease, liver injury, pulmonary fibrogenesis, Alzheimer's disease, acute lung injury, endometritis, cervical carcinogenesis, lung cancer and osteoarthritis. Analytical data of present work revealed the significance of modern Bioanalytical tools for the separation, identification and isolation of engeletin. CONCLUSION From the analysis of scientific research data, we can conclude that engeletin is an important phytochemical, with numerous biological potential in the medicine and other allied health sectors.

Biological potential and antioxidant activity of strictinin in the medicine through literature data analysis

Abstract: Background: Herbal drugs and their derived phytochemical have been used in the medicine for the treatment of human disease and complication. Citrus limon, Ricinus communis, Mangifera indica and Zingiber officinalis are the best examples of commonly used plant material as food material which have been proven their therapeutic effectiveness against various types of viral diseases. Strictinin is an important phytoconstituents found to be present in the Myrothamnus flabellifolius. Methods: Biological potential of strictinin has been investigated in the medicine through literature data analysis of different scientific research work. Numerous scientific data has been collected from different literature databases and analyzed in the present work to know the antioxidant potential of strictinin. Results: Biological potential and antioxidant potential of strictinin in the medicine has been investigated through literature data analysis of different scientific research work and revealed significant effect against lipid peroxidation. In some other scientific research work strictinin exhibited strong scavenging potential. Conclusion: Literature data analysis signified the antioxidant potential of strictinin in the medicine.

Biological importance of cirsiliol on xanthine oxidase for the treatment of renal disorders: Medicinal uses and therapeutic importance

Abstract: Background: Plant secondary metabolite has been used in the modern medicine for the preparation of different formulations. Cirsiliol is an important phytoconstituents of Achillea fragrantissima, Artemisia scoparia and Centaurea jacea. Cirsiliol have been well tested for their effectiveness in the medicine against various form of inflammatory disorders. Methods: Therapeutic benefit of cirsiliol in the medicine has been investigated in the present work through literature data analysis of various scientific research works. Biological potential of cirsiliol against xanthine oxidase has been investigated through literature data analysis of various scientific research works. However therapeutic effectiveness of cirsiliol for their tyrosinase inhibitory activities has been investigated through literature data analysis. Results: Literature data analysis revealed the biological importance of cirsiliol in the medicine against various form of kidney disorders as it showed therapeutic benefit against anti-xanthine oxidase activity. However literature data analysis also revealed the biological potential of cirsiliol in the medicine for their better antioxidant potential which could be used for the treatment of oxidative induced disorders. Conclusion: Literature data analysis revealed the health beneficial properties of cirsiliol in the medicine for their role against xanthine oxidase.