D
Dingbin Chen
Researcher at Guangzhou Medical University
Publications - 11
Citations - 662
Dingbin Chen is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 4, co-authored 8 publications receiving 398 citations.
Papers
More filters
Journal ArticleDOI
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.
Jing Sun,Zhen Zhuang,Jian Zheng,Kun Li,Roy Lok-Yin Wong,Donglan Liu,Jicheng Huang,Jiangping He,Airu Zhu,Jingxian Zhao,Xiaobo Li,Yin Xi,Rongchang Chen,Abeer N. Alshukairi,Zhao Chen,Zhaoyong Zhang,Chunke Chen,Xiaofang Huang,Fang Li,Xiaomin Lai,Dingbin Chen,Liyan Wen,Jianfen Zhuo,Yanjun Zhang,Yanqun Wang,Shuxiang Huang,Jun Dai,Yongxia Shi,Kui Zheng,Mariah R. Leidinger,Jiekai Chen,Yimin Li,Nanshan Zhong,David K. Meyerholz,Paul B. McCray,Stanley Perlman,Jincun Zhao +36 more
TL;DR: A murine model of broad and immediate utility is described to investigate COVID-19 pathogenesis, and to evaluate new therapies and vaccines.
Posted ContentDOI
Hypokalemia and Clinical Implications in Patients with Coronavirus Disease 2019 (COVID-19)
TL;DR: The exciting finding was that patients responded well to K+ supplements when they were inclined to recovery, indicating a good prognosis and may be a reliable, in-time, and sensitive biomarker directly reflecting the end of adverse effect on RAS system.
Journal ArticleDOI
Mapping and role of T cell response in SARS-CoV-2-infected mice.
Zhen Zhuang,Xiaomin Lai,Jing Sun,Zhao Chen,Zhaoyong Zhang,Jun Dai,Donglan Liu,Yuming Li,Fang Li,Yanqun Wang,Airu Zhu,J Wang,Wenhui Yang,Jicheng Huang,Xiaobo Li,Lingfei Hu,Liyan Wen,Jianfen Zhuo,Yanjun Zhang,Dingbin Chen,Suxiang Li,Shuxiang Huang,Yongxia Shi,Kui Zheng,Nanshan Zhong,Jingxian Zhao,Dongsheng Zhou,Jincun Zhao +27 more
TL;DR: In this paper, the authors used mice sensitized for infection with SARS-CoV-2 by transduction with an adenovirus expressing the human receptor (Ad5-hACE2).
Posted ContentDOI
Single-Cell Analysis Reveals Macrophage-Driven T Cell Dysfunction in Severe COVID-19 Patients
Xiaoqing Liu,Airu Zhu,Jiangping He,Zhao Chen,Longqi Liu,Yuanda Xu,Feng Ye,Huijian Feng,Ling Luo,Baomei Cai,Yuanbang Mai,Lihui Lin,Zhenkun Zhuang,Sibei Chen,Junjie Shi,Liyan Wen,Yuanjie Wei,Jianfen Zhuo,Yingying Zhao,Fang Li,Xiaoyu Wei,Dingbin Chen,Xinmei Zhang,Na Zhong,Yaling Huang,He Liu,Jinyong Wang,Xun Xu,Jie Wang,Ruchong Chen,Xinwen Chen,Nanshan Zhong,Jingxian Zhao,Yimin Li,Jincun Zhao,Jiekai Chen +35 more
TL;DR: It is suggested that severe SARS-CoV-2 infection causes immune dysregulation by inducing M2 polarization and subsequent T cell exhaustion and this study improves the understanding of COVID-19 pathogenesis.
Journal ArticleDOI
Development of a Broadly Applicable Cas12a-Linked Beam Unlocking Reaction for Sensitive and Specific Detection of Respiratory Pathogens Including SARS-CoV-2.
Yu Wang,Yu Wang,Donglan Liu,Huihuang Lin,Dingbin Chen,Jing Sun,Yusang Xie,Xinjie Wang,Peixiang Ma,Yan Nie,Hong Mei,Baihui Zhao,Xingxu Huang,Ge Jiang,Xianxing Jiang,Jieming Qu,Jincun Zhao,Jia Liu,Jia Liu +18 more
TL;DR: Wang et al. as discussed by the authors proposed a Cas12a-linked beam unlocking reaction (CALIBURN) to detect SARS-CoV-2 and other coronavirus and influenza viruses with little cross-reactivity.