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Xinwen Chen
Researcher at Guangzhou Institutes of Biomedicine and Health
Publications - 14
Citations - 741
Xinwen Chen is an academic researcher from Guangzhou Institutes of Biomedicine and Health. The author has contributed to research in topics: Virion assembly & NS3. The author has an hindex of 9, co-authored 14 publications receiving 458 citations. Previous affiliations of Xinwen Chen include Chinese Academy of Sciences.
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Journal ArticleDOI
Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient.
Jing Sun,Airu Zhu,Heying Li,Kui Zheng,Zhen Zhuang,Zhao Chen,Yongxia Shi,Zhaoyong Zhang,Si bei Chen,Xuesong Liu,Jun Dai,Xiaobo Li,Shuxiang Huang,Xiaofang Huang,Ling Luo,Liyan Wen,Jianfen Zhuo,Yuming Li,Yanqun Wang,Lu Zhang,Yanjun Zhang,Fang Li,Liqiang Feng,Xinwen Chen,Nanshan Zhong,Zifeng Yang,Jicheng Huang,Jincun Zhao,Yimin Li +28 more
TL;DR: In conclusion, infectious SARS-CoV-2 was successfully isolated from urine of a COVID-19 patient and could infect new susceptible cells and was recognized by its’ own patient sera.
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An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques.
Liqiang Feng,Liqiang Feng,Qian Wang,Qian Wang,Chao Shan,Chenchen Yang,Ying Feng,Jia Wu,Liu Xiaolin,Yiwu Zhou,Ren-Di Jiang,Peiyu Hu,Xinglong Liu,Fan Zhang,Pingchao Li,Xuefeng Niu,Yichu Liu,Xuehua Zheng,Jia Luo,Jing Sun,Yingying Gu,Bo Liu,Yongcun Xu,Chufang Li,Weiqi Pan,Jincun Zhao,Changwen Ke,Xinwen Chen,Tao Xu,Nanshan Zhong,Guan Suhua,Zhiming Yuan,Ling Chen,Ling Chen +33 more
TL;DR: A replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike is generated, protection from infection in non-human primates is shown, and the immune response after intramuscular and intranasal vaccination is analyzed.
Journal ArticleDOI
Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients.
Jiangping He,Shuijiang Cai,Huijian Feng,Baomei Cai,Lihui Lin,Yuanbang Mai,Yinqiang Fan,Airu Zhu,Huang Huang,Junjie Shi,Dingxin Li,Yuanjie Wei,Yueping Li,Yingying Zhao,Yuejun Pan,He Liu,Xiaoneng Mo,Xi He,Shangtao Cao,Feng Yu Hu,Jincun Zhao,Jie Wang,Nanshan Zhong,Xinwen Chen,Xilong Deng,Jiekai Chen +25 more
TL;DR: The leukocytes and epithelial cells in the bronchoalveolar lavage fluid (BALF) from 3 severe COVID-19 patients are reported and the SARS-CoV-2 infection-induced ARDS at the cellular and molecular levels are investigated.
Journal ArticleDOI
Dengue NS2A Protein Orchestrates Virus Assembly.
Xuping Xie,Jing Zou,Xianwen Zhang,Xianwen Zhang,Yiyang Zhou,Andrew Routh,CongBao Kang,Vsevolod L. Popov,Xinwen Chen,Xinwen Chen,Qing Yin Wang,Hongping Dong,Pei Yong Shi +12 more
TL;DR: It is shown that dengue nonstructural protein 2A (NS2A protein) recruits viral RNA, structural proteins, and protease to the site of virion assembly and coordinates nucleocapsid and virus formation.
Journal ArticleDOI
Zika Virus NS2A-Mediated Virion Assembly
Xianwen Zhang,Xianwen Zhang,Xuping Xie,Hongjie Xia,Jing Zou,Linfen Huang,Vsevolod L. Popov,Xinwen Chen,Xinwen Chen,Pei Yong Shi +9 more
TL;DR: ZIKV NS2A plays a central role in recruiting viral RNA, structural protein prM/E, and viral NS2B/NS3 protease to the virion assembly site and orchestrates virus morphogenesis, demonstrating the specific role of these interactions in virus Morphogenesis.