D
Dirk M. Anderson
Researcher at Amgen
Publications - 84
Citations - 17476
Dirk M. Anderson is an academic researcher from Amgen. The author has contributed to research in topics: Receptor & RANKL. The author has an hindex of 38, co-authored 84 publications receiving 17013 citations. Previous affiliations of Dirk M. Anderson include Kumamoto University & Roswell Park Cancer Institute.
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Journal ArticleDOI
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
Dirk M. Anderson,Eugene Maraskovsky,William L. Billingsley,William C. Dougall,Mark E. Tometsko,Eileen R. Roux,Mark Teepe,Robert F. DuBose,David Cosman,Laurent J. Galibert +9 more
TL;DR: RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells.
Journal ArticleDOI
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
Kenneth H. Grabstein,June R. Eisenman,Kurt D. Shanebeck,Charles Rauch,Subhashini Srinivasan,Victor Fung,Courtney Beers,Jane S. Richardson,Michael A. Schoenborn,Minoo Ahdieh,Lisabeth Johnson,Mark R. Alderson,James D. Watson,Dirk M. Anderson,Judith G. Giri +14 more
TL;DR: A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated, indicating that IL-15 uses components of the IL-2 receptor.
Journal ArticleDOI
RANK is essential for osteoclast and lymph node development.
William C. Dougall,Moira Glaccum,Keith Charrier,Kathy Rohrbach,Kenneth Brasel,T De Smedt,E Daro,Jeffrey S. Smith,Mark E. Tometsko,C. R. Maliszewski,Allison P. Armstrong,V Shen,S Bain,David Cosman,Dirk M. Anderson,Philip J. Morrissey,Jacques J. Peschon,JoAnn C. L. Schuh +17 more
TL;DR: Investigating the physiological role of the TNF receptor (TNFR) family member, RANK, revealed that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation.
Journal ArticleDOI
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins
Craig A. Smith,T Davis,Dirk M. Anderson,L Solam,MP Beckmann,Rita Jerzy,Steven K. Dower,David Cosman,Raymond G. Goodwin +8 more
TL;DR: The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.
Journal ArticleDOI
Molecular and biological characterization of a murine ligand for CD40
Richard J. Armitage,William C. Fanslow,Laura Strockbine,Timothy A. Sato,Ky N. Clifford,Brian M. Macduff,Dirk M. Anderson,Steven D. Gimpel,Terri Davis-Smith,Charles R. Maliszewski,Edward A. Clark,Craig A. Smith,Kenneth H. Grabstein,David Cosman,Melanie K. Spriggs +14 more
TL;DR: The cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interIeukin-4 is reported.