J
Judith G. Giri
Researcher at Roswell Park Cancer Institute
Publications - 10
Citations - 3502
Judith G. Giri is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Receptor & Interleukin 15. The author has an hindex of 8, co-authored 10 publications receiving 3383 citations.
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Journal ArticleDOI
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
Kenneth H. Grabstein,June R. Eisenman,Kurt D. Shanebeck,Charles Rauch,Subhashini Srinivasan,Victor Fung,Courtney Beers,Jane S. Richardson,Michael A. Schoenborn,Minoo Ahdieh,Lisabeth Johnson,Mark R. Alderson,James D. Watson,Dirk M. Anderson,Judith G. Giri +14 more
TL;DR: A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated, indicating that IL-15 uses components of the IL-2 receptor.
Journal ArticleDOI
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.
William E. Carson,Judith G. Giri,Matthew J. Lindemann,Michael L. Linett,Minoo Ahdieh,Raymond J. Paxton,Dirk M. Anderson,June Eisenmann,Kenneth H. Grabstein,Michael A. Caligiuri +9 more
TL;DR: A functional analysis of recombinant IL-15 on phenotypically and functionally distinct populations of highly purified human natural killer (NK) cells revealed the presence of high and intermediate affinity receptors for both ligands.
Journal ArticleDOI
Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
Dirk M. Anderson,Satoru Kumaki,Minoo Ahdieh,Jeanette S. Bertles,Mark E. Tometsko,Aaron Loomis,Judith G. Giri,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Virginia Valentine,David N. Shapiro,Stephan W. Morris,Linda S. Park,David Cosman +14 more
TL;DR: The isolation of three differentially spliced human IL-15Rα variants that are all capable of high affinity binding ofIL-15 are extended into the human system, suggesting a broader range of cellular targets for IL- 15.
Journal ArticleDOI
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor
Raymond G. Goodwin,Mark R. Alderson,Craig A. Smith,Richard J. Armitage,Tim VandenBos,Rita Jerzy,Teresa W. Tough,Michael A. Schoenborn,Terri Davis-Smith,Kathryn B. Hennen,Ben A. Falk,David Cosman,Elizabeth Baker,Grant R. Sutherland,Kenneth H. Grabstein,Terry Farrah,Judith G. Giri,M. Patricia Beckmann +17 more
TL;DR: Biological characterization indicates that the cloned ligand induces the proliferation of costimulated T cells and enhances the generation of cytolytic T cells.
Journal ArticleDOI
IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2.
Judith G. Giri,Dirk M. Anderson,Satoru Kumaki,Linda S. Park,Kenneth H. Grabstein,David Cosman +5 more
TL;DR: Differences in the expression pattern of IL-15 and its receptor compared to the IL-2 system suggest unique in vivo roles for IL-teen, which may contribute to the phenotype of X-linked severe combined immunodeficiency in humans, resulting from mutations in the common gamma chain.