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William C. Fanslow
Researcher at Amgen
Publications - 102
Citations - 13667
William C. Fanslow is an academic researcher from Amgen. The author has contributed to research in topics: CD40 & Antibody. The author has an hindex of 51, co-authored 101 publications receiving 13312 citations. Previous affiliations of William C. Fanslow include Science Applications International Corporation.
Papers
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Journal ArticleDOI
ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor
David Cosman,Jürgen Müllberg,Claire L. Sutherland,Wilson Chin,Richard J. Armitage,William C. Fanslow,Marek Kubin,N. Jan Chalupny +7 more
TL;DR: Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack by the immune system.
Journal ArticleDOI
Molecular and biological characterization of a murine ligand for CD40
Richard J. Armitage,William C. Fanslow,Laura Strockbine,Timothy A. Sato,Ky N. Clifford,Brian M. Macduff,Dirk M. Anderson,Steven D. Gimpel,Terri Davis-Smith,Charles R. Maliszewski,Edward A. Clark,Craig A. Smith,Kenneth H. Grabstein,David Cosman,Melanie K. Spriggs +14 more
TL;DR: The cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interIeukin-4 is reported.
Journal Article
Human IL-17: a novel cytokine derived from T cells.
Zhengbin Yao,Sally L. Painter,William C. Fanslow,D. Ulrich,B M Macduff,M K Spriggs,Richard J. Armitage +6 more
TL;DR: A cDNA encoding human IL-17 (hIL-17) was cloned from a CD4+ T cell library and contains an N-terminal signal peptide and exhibits 72% amino acid identity with HVS13, an open reading frame from a T-lymphotropic Herpesvirus saimiri, and 63% with murine CTLA8.
Journal ArticleDOI
Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
Zhengbin Yao,William C. Fanslow,Michael F. Seldin,Anne-Marie C Rousseau,Sally L. Painter,Michael R. Comeau,Jeffrey I. Cohen,Melanie K. Spriggs +7 more
TL;DR: Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8, which is defined as novel cytokines that bind to a novel cytokine receptor and proposed to call these molecules IL- 17, vIL-17, and IL-17R.
Journal ArticleDOI
CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
R. Cutler Allen,Richard J. Armitage,Mary Ellen Conley,Howard M. Rosenblatt,Nancy A. Jenkins,Neal G. Copeland,Mary A. Bedell,Susanne Edelhoff,Christine M. Disteche,Denise K. Simoneaux,William C. Fanslow,John W. Belmont,Melanie K. Spriggs +12 more
TL;DR: Abnormalities in the CD40L gene were associated with an X-linked immunodeficiency in humans [hyper-IgM (immunoglobulin M) syndrome], characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes.