P
Philip J. Morrissey
Researcher at Millipore Corporation
Publications - 55
Citations - 11033
Philip J. Morrissey is an academic researcher from Millipore Corporation. The author has contributed to research in topics: Population & T cell. The author has an hindex of 39, co-authored 55 publications receiving 10661 citations. Previous affiliations of Philip J. Morrissey include Washington University in St. Louis.
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Journal ArticleDOI
Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
Mary K. Kennedy,Moira Glaccum,Sandra N. Brown,Eric A. Butz,Joanne L. Viney,Monica E. Embers,Naoto Matsuki,Keith Charrier,Lisa M. Sedger,Cynthia R. Willis,Kenneth Brasel,Philip J. Morrissey,Kim L. Stocking,JoAnn C. L. Schuh,Sebastian Joyce,Jacques J. Peschon +15 more
TL;DR: Critical roles for IL-15 in the development of specific lymphoid lineages are revealed and the ability to rescue lymphoid defects inIL-15−/− mice by IL- 15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine.
Journal ArticleDOI
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
J J Peschon,Philip J. Morrissey,Kenneth H. Grabstein,F J Ramsdell,E Maraskovsky,Brian C. Gliniak,L S Park,Steven F. Ziegler,D E Williams,C B Ware,J. Meyer,B L Davison +11 more
TL;DR: In this paper, the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL7R was examined and it was shown that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL7.
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RANK is essential for osteoclast and lymph node development.
William C. Dougall,Moira Glaccum,Keith Charrier,Kathy Rohrbach,Kenneth Brasel,T De Smedt,E Daro,Jeffrey S. Smith,Mark E. Tometsko,C. R. Maliszewski,Allison P. Armstrong,V Shen,S Bain,David Cosman,Dirk M. Anderson,Philip J. Morrissey,Jacques J. Peschon,JoAnn C. L. Schuh +17 more
TL;DR: Investigating the physiological role of the TNF receptor (TNFR) family member, RANK, revealed that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation.
Journal ArticleDOI
CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.
TL;DR: Interestingly, mice that received mixtures of whole lymph node or purified CD4+ cells with CD4-/CD45RBhi cells did not develop weight loss, indicating that the unseparatedCD4+ population contained cells that were capable of regulating the reactivity of the CD4+.
Journal ArticleDOI
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor.
Linda S. Park,Unja Martin,Kirsten E. Garka,Brian C. Gliniak,James P. Di Santo,Werner Müller,David A. Largaespada,Neal G. Copeland,Nancy A. Jenkins,Andrew G. Farr,Steven F. Ziegler,Philip J. Morrissey,Raymond J. Paxton,John E. Sims +13 more
TL;DR: The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding.