M
Moira Glaccum
Researcher at Amgen
Publications - 11
Citations - 5698
Moira Glaccum is an academic researcher from Amgen. The author has contributed to research in topics: Cytokine & Cytotoxic T cell. The author has an hindex of 10, co-authored 11 publications receiving 5462 citations.
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Journal ArticleDOI
Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
Mary K. Kennedy,Moira Glaccum,Sandra N. Brown,Eric A. Butz,Joanne L. Viney,Monica E. Embers,Naoto Matsuki,Keith Charrier,Lisa M. Sedger,Cynthia R. Willis,Kenneth Brasel,Philip J. Morrissey,Kim L. Stocking,JoAnn C. L. Schuh,Sebastian Joyce,Jacques J. Peschon +15 more
TL;DR: Critical roles for IL-15 in the development of specific lymphoid lineages are revealed and the ability to rescue lymphoid defects inIL-15−/− mice by IL- 15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine.
Journal ArticleDOI
RANK is essential for osteoclast and lymph node development.
William C. Dougall,Moira Glaccum,Keith Charrier,Kathy Rohrbach,Kenneth Brasel,T De Smedt,E Daro,Jeffrey S. Smith,Mark E. Tometsko,C. R. Maliszewski,Allison P. Armstrong,V Shen,S Bain,David Cosman,Dirk M. Anderson,Philip J. Morrissey,Jacques J. Peschon,JoAnn C. L. Schuh +17 more
TL;DR: Investigating the physiological role of the TNF receptor (TNFR) family member, RANK, revealed that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation.
Journal Article
TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation
Jacques J. Peschon,Dauphine S. Torrance,Kim L. Stocking,Moira Glaccum,Carol Otten,Cynthia R. Willis,Keith Charrier,Philip J. Morrissey,Carol B. Ware,Kendall M. Mohler +9 more
TL;DR: The biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF are clarified and genetic evidence for an antagonistic role of p75 is provided in vivo.
Journal ArticleDOI
Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice
TL;DR: Results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells and confirmed the key role of TRAIL in suppressing tumor initiation and metastasis.
Journal ArticleDOI
Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells
Ananda W. Goldrath,Pallavur V. Sivakumar,Moira Glaccum,Mary K. Kennedy,Michael J. Bevan,Christophe Benoist,Diane Mathis,Eric A. Butz +7 more
TL;DR: The results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memoryT lymphocytes have distinct requirements for proliferation in full versus empty compartments.