K
Kenneth H. Grabstein
Researcher at Corixa Corporation
Publications - 118
Citations - 19437
Kenneth H. Grabstein is an academic researcher from Corixa Corporation. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 62, co-authored 118 publications receiving 18930 citations. Previous affiliations of Kenneth H. Grabstein include Washington University in St. Louis & Roswell Park Cancer Institute.
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Journal ArticleDOI
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Carl J. March,Bruce Mosley,Larsen Alf D,Douglas P. Cerretti,Gary Braedt,Virginia L. Price,Steven Gillis,Christopher S. Henney,Shirley R. Kronheim,Kenneth H. Grabstein,Paul J. Conlon,Thomas P. Hopp,David Cosman +12 more
TL;DR: Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library.
Journal ArticleDOI
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
J J Peschon,Philip J. Morrissey,Kenneth H. Grabstein,F J Ramsdell,E Maraskovsky,Brian C. Gliniak,L S Park,Steven F. Ziegler,D E Williams,C B Ware,J. Meyer,B L Davison +11 more
TL;DR: In this paper, the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL7R was examined and it was shown that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL7.
Journal ArticleDOI
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
Kenneth H. Grabstein,June R. Eisenman,Kurt D. Shanebeck,Charles Rauch,Subhashini Srinivasan,Victor Fung,Courtney Beers,Jane S. Richardson,Michael A. Schoenborn,Minoo Ahdieh,Lisabeth Johnson,Mark R. Alderson,James D. Watson,Dirk M. Anderson,Judith G. Giri +14 more
TL;DR: A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated, indicating that IL-15 uses components of the IL-2 receptor.
Journal ArticleDOI
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
Andrew W. Sylwester,Bridget L. Mitchell,John B. Edgar,Cara Taormina,Christian Pelte,Franziska Ruchti,Paul R. Sleath,Kenneth H. Grabstein,Nancy Ann Hosken,Florian Kern,Jay A. Nelson,Louis J. Picker +11 more
TL;DR: The first glimpse of the total human T cell response to a complex infectious agent is provided and insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans is provided.
Journal ArticleDOI
Molecular and biological characterization of a murine ligand for CD40
Richard J. Armitage,William C. Fanslow,Laura Strockbine,Timothy A. Sato,Ky N. Clifford,Brian M. Macduff,Dirk M. Anderson,Steven D. Gimpel,Terri Davis-Smith,Charles R. Maliszewski,Edward A. Clark,Craig A. Smith,Kenneth H. Grabstein,David Cosman,Melanie K. Spriggs +14 more
TL;DR: The cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interIeukin-4 is reported.