D
Doke C.R. Wahrer
Researcher at Harvard University
Publications - 14
Citations - 3546
Doke C.R. Wahrer is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 13, co-authored 14 publications receiving 3404 citations.
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Journal ArticleDOI
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
Daphne W. Bell,Jennifer M. Varley,Tara E. Szydlo,Deborah H. Kang,Doke C.R. Wahrer,Kristen E. Shannon,Marcie L. Lubratovich,Sigitas Verselis,Kurt J. Isselbacher,Joseph F. Fraumeni,Jillian M. Birch,Frederick P. Li,Judy Garber,Daniel A. Haber +13 more
TL;DR: HCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors, and the central role of p53 inactivation in human cancer and the well-defined G2 checkpoint in yeast is provided.
Journal ArticleDOI
salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines
Nicolas Tapon,Kieran F. Harvey,Daphne W. Bell,Doke C.R. Wahrer,Taryn A. Schiripo,Daniel A. Haber,Iswar K. Hariharan +6 more
TL;DR: Salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis.
Journal ArticleDOI
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Sharon B. Cantor,Daphne W. Bell,Shridar Ganesan,Elizabeth M. Kass,Ronny Drapkin,Steven R. Grossman,Doke C.R. Wahrer,Dennis C. Sgroi,William S. Lane,Daniel A. Haber,David M. Livingston +10 more
TL;DR: A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its BRCA1 binding function.
Journal ArticleDOI
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
TL;DR: It is shown thatarchipelago mutant cells have persistently elevated levels of Cyclin E protein without increased levels of cyclin E RNA, which implicate archipelago in developmentally regulated degradation of CyclIn E and potentially in the pathogenesis of human cancers.
Journal ArticleDOI
DOCK4, a GTPase activator, is disrupted during tumorigenesis.
Vijay Yajnik,Charles Paulding,Raffaella Sordella,Andrea I. McClatchey,Mako Saito,Doke C.R. Wahrer,Paul A. Reynolds,Daphne W. Bell,Robert J. Lake,Sander van den Heuvel,Jeff Settleman,Daniel A. Haber +11 more
TL;DR: A deletion targeting DOCK4, a member of the CDM gene family encoding regulators of small GTPases, is described, which encodes a CDM family member that regulates intercellular junctions and is disrupted during tumorigenesis.