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Iswar K. Hariharan
Researcher at University of California, Berkeley
Publications - 90
Citations - 10224
Iswar K. Hariharan is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Imaginal disc & Gene. The author has an hindex of 44, co-authored 88 publications receiving 9584 citations. Previous affiliations of Iswar K. Hariharan include Harvard University & Cold Spring Harbor Laboratory.
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Comparative Genomics of the Eukaryotes
Gerald M. Rubin,Mark Yandell,Jennifer R. Wortman,George L. Gabor,Miklos,Catherine R. Nelson,Iswar K. Hariharan,Mark E. Fortini,Peter W. Li,Rolf Apweiler,Wolfgang Fleischmann,J. Michael Cherry,Steven Henikoff,Marian P. Skupski,Sima Misra,Michael Ashburner,Ewan Birney,Mark S. Boguski,Thomas Brody,Peter Brokstein,Susan E. Celniker,Stephen A. Chervitz,David Coates,Anibal Cravchik,Andrei Gabrielian,Richard F. Galle,William M. Gelbart,Reed A. George,Lawrence S.B. Goldstein,Fangcheng Gong,Ping Guan,Nomi L. Harris,Bruce A. Hay,Roger A. Hoskins,Jiayin Li,Zhenya Li,Richard O. Hynes,Steven J.M. Jones,Peter M. Kuehl,Bruno Lemaitre,J. Troy Littleton,Deborah K. Morrison,Christopher J. Mungall,Patrick H. O'Farrell,Oxana K. Pickeral,Chris Shue,Leslie B. Vosshall,Jiong Zhang,Qi Zhao,Xiangqun H. Zheng,Fei Zhong,Wenyan Zhong,Richard A. Gibbs,J. Craig Venter,Mark Raymond Adams,Suzanna E. Lewis +55 more
TL;DR: The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
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The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis
TL;DR: Hpo links Sav and Wts to a key regulator of apoptosis, which results in increased tissue growth and impaired apoptosis characterized by elevated levels of the cell cycle regulator cyclin E and apoptosis inhibitor DIAP1.
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salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines
Nicolas Tapon,Kieran F. Harvey,Daphne W. Bell,Doke C.R. Wahrer,Taryn A. Schiripo,Daniel A. Haber,Iswar K. Hariharan +6 more
TL;DR: Salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis.
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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.
TL;DR: Mutations in the Drosophila Tsc1 and Tsc2/gigas genes are characterized, finding that in postmitotic mutant cells, levels of Cyclin E and Cyclin A are elevated, which correlates with a tendency for these cells to reenter the cell cycle inappropriately as is observed in the human lesions.
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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
TL;DR: It is shown thatarchipelago mutant cells have persistently elevated levels of Cyclin E protein without increased levels of cyclin E RNA, which implicate archipelago in developmentally regulated degradation of CyclIn E and potentially in the pathogenesis of human cancers.