D
Domenico Maglione
Researcher at International Institute of Minnesota
Publications - 25
Citations - 3312
Domenico Maglione is an academic researcher from International Institute of Minnesota. The author has contributed to research in topics: Vascular endothelial growth factor A & Vascular endothelial growth factor. The author has an hindex of 14, co-authored 23 publications receiving 3239 citations. Previous affiliations of Domenico Maglione include University of Naples Federico II.
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Journal ArticleDOI
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.
TL;DR: It is demonstrated that PlGF, derived from transfected COS-1 cells, is actually N-glycosylated and secreted into the medium and, like VPF, proves to be a dimeric protein.
Journal ArticleDOI
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Monica Autiero,Johannes Waltenberger,Didier Communi,Andrea Kranz,Lieve Moons,Diether Lambrechts,Jens Kroll,Stéphane Plaisance,Maria De Mol,Françoise Bono,Stefanie Kliche,Guido Fellbrich,Kurt Ballmer-Hofer,Domenico Maglione,Ulrike Mayr-Beyrle,Mieke Dewerchin,Saskia Dombrowski,Danica Stanimirovic,Paul Van Hummelen,Christoph Dehio,Daniel J. Hicklin,Graziella Persico,Jean-Marc Herbert,David Communi,Masabumi Shibuya,Desire Collen,Edward M. Conway,Peter Carmeliet +27 more
TL;DR: It is reported that placental growth factor (PGF) regulates inter- and intramolecular cross talk between the VEGF RTKs Flt1 and Flk1, which is likely to have therapeutic implications, as treatment with VegF/PGF heterodimer or a combination of VEGf plus PGF increased ischemic myocardial angiogenesis in a mouse model that was refractory to V EGF alone.
Journal Article
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.
Domenico Maglione,Guerriero,Giuseppe Viglietto,Ferraro Mg,Olga Aprelikova,Kari Alitalo,Del Vecchio S,Lei Kj,Chou Jy,M. G. Persico +9 more
TL;DR: Preliminary results indicate that the PIGF gene has been conserved in evolution, since the human PlGF cDNA hybridizes to sequences present in the genomic DNA of Drosophila, Xenopus, chicken and mouse.
Journal Article
Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic
Marina Ziche,Domenico Maglione,Domenico Ribatti,Lucia Morbidelli,C. T. Lago,M. Battisti,I. Paoletti,A. Barra,Marina Tucci,G. Parise,V. Vincenti,Harris J. Granger,Giuseppe Viglietto,M. G. Persico +13 more
TL;DR: This is the first study to demonstrate that PIGF-1 can induce angiogenesis in vivo and stimulate the migration and proliferation of endothelial cells in vitro.
Journal Article
Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines.
Giuseppe Viglietto,Domenico Maglione,M. Rambaldi,J Cerutti,A Romano,Francesco Trapasso,Monica Fedele,P Ippolito,Gennaro Chiappetta,Gerardo Botti +9 more
TL;DR: It is shown that both the V EGF receptors, FLT-1 and flk/KDR, are expressed in endothelial cells that line tumor-embedded microvascular vessels, suggesting that VEGF but not PlGF, contributes to thyroid tumor development.