L
Li Yu
Researcher at Shenzhen University
Publications - 245
Citations - 5973
Li Yu is an academic researcher from Shenzhen University. The author has contributed to research in topics: DNA methylation & Myeloid leukemia. The author has an hindex of 32, co-authored 237 publications receiving 5267 citations. Previous affiliations of Li Yu include Chinese PLA General Hospital & Tsinghua University.
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Journal ArticleDOI
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
Joseph F. Costello,Joseph F. Costello,Michael C. Frühwald,Michael C. Frühwald,Dominic J. Smiraglia,Laura J. Rush,Gavin P. Robertson,Xin Gao,Fred A. Wright,Jamison D. Feramisco,Päivi Peltomäki,James C. Lang,David E. Schuller,Li Yu,Clara D. Bloomfield,Michael A. Caligiuri,Allan J. Yates,Ryo Nishikawa,H.-J. Su Huang,Nicholas J. Petrelli,Xueli Zhang,M. S. O'Dorisio,William A. Held,Webster K. Cavenee,Webster K. Cavenee,Christoph Plass +25 more
TL;DR: This report reports a global analysis of the methylation status of 1,184 unselected CpG islands in each of 98 primary human tumours using restriction landmark genomic scanning (RLGS), and estimates that an average of 600 C pG islands were aberrantly methylated in the tumours, including early stage tumours.
Journal ArticleDOI
Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma
Yuan Kai Shi,M. Dong,X. Hong,W. Zhang,J. Feng,J. Zhu,Li Yu,X. Ke,H.Q. Huang,Zan Shen,Y. Fan,Wei Li,X. Zhao,J. Qi,D. Zhou,Z. Ning,X. Lu +16 more
TL;DR: Chidamide represents a novel oral benzamide class of HDAC inhibitor with significant single-agent activity and manageable toxicity in relapsed or refractory PTCL, and provides a much needed treatment option in this indication in China.
Journal ArticleDOI
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
Frank Rosenbauer,Frank Rosenbauer,Bronwyn M. Owens,Li Yu,Joseph R. Tumang,Ulrich Steidl,Jeffery L. Kutok,Linda K. Clayton,Katharina Wagner,Katharina Wagner,Marina Scheller,Hiromi Iwasaki,Chunhui Liu,Björn Hackanson,Koichi Akashi,Achim Leutz,Thomas L. Rothstein,Christoph Plass,Daniel G. Tenen +18 more
TL;DR: It is shown that the URE has an essential role in orchestrating the dynamic PU.1 expression pattern required for lymphoid development and tumor suppression, and epigenetic silencing of selective tumor suppressor genes completed the transformation of lymphoid progenitors with URE deletion.
Journal ArticleDOI
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia
Li Yu,Chunhui Liu,Jeff Vandeusen,Brian Becknell,Zunyan Dai,Yue Zhong Wu,Aparna Raval,Te Hui Liu,Wei Ding,Charlene Mao,Shujun Liu,Laura T. Smith,Stephen Lee,Laura Z. Rassenti,Guido Marcucci,John C. Byrd,Michael A. Caligiuri,Christoph Plass +17 more
TL;DR: This work developed a mouse model of T/natural killer acute lymphoblastic leukemia that is always preceded by polyclonal lymphocyte expansion to determine how aberrant promoter DNA methylation and consequent gene silencing might be contributing to leukemic transformation.
Journal ArticleDOI
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome
Cinzia Allegrucci,Yue Zhong Wu,Alexandra Thurston,Chris Denning,Helen Priddle,Christine L. Mummery,Dorien Ward-van Oostwaard,Peter W. Andrews,Miodrag Stojkovic,Nigel Smith,Tony Parkin,Mark Edmondson Jones,Graham Warren,Li Yu,Romulo M. Brena,Christoph Plass,Lorraine E. Young +16 more
TL;DR: Current methods of hESC propagation can rapidly programme stable and unpredictable epigenetic changes in the stem cell genome, which highlights the need for novel screening strategies and standardization of procedures for the derivation and culture of h ESC lines that minimize culture-induced instability.