Dominic J. Withers

TL;DR: Inactivated S6K1 in pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, key regulators of energy homeostasis, is inactivated, suggesting that S 6K1 signaling is not a general integrator of energyHomeostasis in the mediobasal hypothalamus but has distinct roles in the regulation of glucose homeostas by POMC and AgRP neurons.

TL;DR: It is shown in mice, that intraperitoneal injection of PYY3-36 or Y2R agonist improves nutrient-stimulated glucose tolerance and enhances insulin secretion; an effect blocked by peripheral, but not central, Y 2R antagonist administration.

TL;DR: Results show that AMPKα2 activity is necessary to maintain normal pancreatic β- cell glucose sensing, possibly by maintaining high β-cell levels of UCP2.

TL;DR: These findings identify SF1 neurons as a key part of the neurocircuitry that controls both feeding and related affective states, giving potential insights into the relationship between disordered eating and stress-associated psychological disorders in humans.

TL;DR: It is demonstrated that MC3R and MC4R agonists depolarize arcuate POMC neurons and a separate arcuate neuronal population identified by the rat insulin 2 promoter (RIPCre) transgene expression, and that PomC and RIPCre neurons may be targets for peptide transmitters that are possibly released locally from AgRP‐expressing and POMM neurons in the arcuate nucleus, adding further previously unappreciated complexity to the arcuates system.