Dominic J. Withers

TL;DR: Tissue-specific differences in the roles of IRSs to mediate insulin action are indicated, with irs-1 playing a prominent role in skeletal muscle and irS-2 in liver and ir/irs-2(+/-) mice developing severe insulin resistance in liver, with compensatory beta-cell hyperplasia.

TL;DR: It is suggested that while AMPK plays a key role in hypothalamic function, it does not act as a general sensor and integrator of energy homeostasis in the mediobasal hypothalamus.

TL;DR: It is shown, using functional magnetic resonance imaging, that peptide YY3–36 (PYY), a physiological gut-derived satiety signal, modulates neural activity within both corticolimbic and higher-cortical areas as well as homeostatic brain regions, giving insights into the neural networks in humans that respond to a specificsatiety signal to regulate food intake.

TL;DR: A critical role for p110 α in growth factor and metabolic signalling is demonstrated and an explanation for selective mutation or overexpression of p110α in a variety of cancers is suggested.

TL;DR: It is shown that deletion of insulin receptor substrate-2 (IRS-2), a component of the insulin/insulin-like growth factor-1 signalling cascade, causes female infertility and indicates that insulin, together with leptin and other neuropeptides, may modulate hypothalamic control of appetite and reproductive endocrinology.