D
Dominik Fröhlich
Researcher at University of New South Wales
Publications - 23
Citations - 1864
Dominik Fröhlich is an academic researcher from University of New South Wales. The author has contributed to research in topics: Biology & Exosome. The author has an hindex of 10, co-authored 16 publications receiving 1432 citations. Previous affiliations of Dominik Fröhlich include University of Mainz.
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Journal ArticleDOI
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Carsten Frühbeis,Dominik Fröhlich,Wen Ping Kuo,Jesa Amphornrat,Sebastian Thilemann,Aiman S. Saab,Frank Kirchhoff,Wiebke Möbius,Sandra Goebbels,Klaus-Armin Nave,Anja Schneider,Mikael Simons,Matthias Klugmann,Jacqueline Trotter,Eva-Maria Krämer-Albers +14 more
TL;DR: Neuronal activity provokes myelinating oligodendrocytes to release exosomes by stimulation of ionotropic glutamate receptors, and that once released, these vesicles are internalized by neurons conveying neuroprotection.
Journal ArticleDOI
Extracellular vesicles as mediators of neuron-glia communication.
TL;DR: Current work has demonstrated that oligodendrocytes transfer exosomes to neurons as a result of neurotransmitter signaling suggesting that these vesicles may mediate glial support of neurons.
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Emerging Roles of Exosomes in Neuron–Glia Communication
TL;DR: The role of exosomes in nervous system cell communication is highlighted with particular focus on exosome released by oligodendrocytes and their potential implications in axon–glia interaction and myelin disease, such as multiple sclerosis.
Journal ArticleDOI
Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation.
Dominik Fröhlich,Wen Ping Kuo,Carsten Frühbeis,Jyh-Jang Sun,Christoph M. Zehendner,Heiko J. Luhmann,Sheena Pinto,Joern Toedling,Jacqueline Trotter,Eva-Maria Krämer-Albers +9 more
TL;DR: It is demonstrated that oligodendroglial exosomes also promote neuronal survival during oxygen–glucose deprivation, a model of cerebral ischaemia and provides new insight into the broad spectrum of action of oligodendingrocytes and their effects on neuronal physiology.
Journal ArticleDOI
Glial promoter selectivity following AAV-delivery to the immature brain.
Georg von Jonquieres,Nadine Mersmann,Claudia B. Klugmann,Anne E. Harasta,Beat Lutz,Orla Teahan,Gary D. Housley,Dominik Fröhlich,Eva-Maria Krämer-Albers,Matthias Klugmann,Matthias Klugmann +10 more
TL;DR: The data suggest that direct AAV infusion to the developing postnatal brain, utilising cellular promoters, results in targeted and long-term transgene expression in glia, relevant for disease modelling and gene therapy for the treatment of glial pathology.