W
Wiebke Möbius
Researcher at Max Planck Society
Publications - 156
Citations - 13413
Wiebke Möbius is an academic researcher from Max Planck Society. The author has contributed to research in topics: Myelin & Oligodendrocyte. The author has an hindex of 51, co-authored 138 publications receiving 10630 citations. Previous affiliations of Wiebke Möbius include University of Göttingen & Utrecht University.
Papers
More filters
Journal ArticleDOI
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Ursula Fünfschilling,Lotti Marianna Supplie,Don J. Mahad,Don J. Mahad,Susann Boretius,Aiman S. Saab,Julia M. Edgar,Bastian G. Brinkmann,Celia M. Kassmann,Iva D. Tzvetanova,Wiebke Möbius,Francisca Diaz,Dies Meijer,Ueli Suter,Bernd Hamprecht,Michael W. Sereda,Carlos T. Moraes,Jens Frahm,Sandra Goebbels,Klaus-Armin Nave +19 more
TL;DR: By in vivo magnetic resonance spectroscopy, brain lactate concentrations in mutants were increased compared with controls, but were detectable only in mice exposed to volatile anaesthetics, which indicates that aerobic glycolysis products derived from oligodendrocytes are rapidly metabolized within white matter tracts.
Journal ArticleDOI
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.
Richard Wubbolts,Rachel S. Leckie,Peter T. M. Veenhuizen,Guenter Schwarzmann,Wiebke Möbius,Joerg Hoernschemeyer,J W Slot,Hans J. Geuze,Willem Stoorvogel +8 more
TL;DR: Data suggest that recruitment of membrane proteins from the limiting membranes into the internal vesicles of multivesicular bodies may involve their incorporation into tetraspanin-containing detergent-resistant membrane domains.
Journal ArticleDOI
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
Chieh Hsu,Yuichi Morohashi,Shin-ichiro Yoshimura,Natalia Manrique-Hoyos,SangYong Jung,Marcel A. Lauterbach,Mostafa Bakhti,Mads Grønborg,Wiebke Möbius,Jeong-Seop Rhee,Francis A. Barr,Mikael Simons +11 more
TL;DR: A screen in oligodendrocytes establishes a Rab family member and its GAPs as regulators of exosome secretion by controlling endocytic vesicle docking with the plasma membrane.
Journal ArticleDOI
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Carsten Frühbeis,Dominik Fröhlich,Wen Ping Kuo,Jesa Amphornrat,Sebastian Thilemann,Aiman S. Saab,Frank Kirchhoff,Wiebke Möbius,Sandra Goebbels,Klaus-Armin Nave,Anja Schneider,Mikael Simons,Matthias Klugmann,Jacqueline Trotter,Eva-Maria Krämer-Albers +14 more
TL;DR: Neuronal activity provokes myelinating oligodendrocytes to release exosomes by stimulation of ionotropic glutamate receptors, and that once released, these vesicles are internalized by neurons conveying neuroprotection.
Journal ArticleDOI
High cholesterol level is essential for myelin membrane growth.
Gesine Saher,Britta Brügger,Corinna Lappe-Siefke,Wiebke Möbius,Ryu-ichi Tozawa,Michael C. Wehr,Felix T. Wieland,Shun Ishibashi,Klaus-Armin Nave +8 more
TL;DR: It is shown that cholesterol is an indispensable component of myelin membranes and that cholesterol availability in oligodendrocytes is a rate-limiting factor for brain maturation.