D
Dominique Pepin
Researcher at Pierre-and-Marie-Curie University
Publications - 13
Citations - 908
Dominique Pepin is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Arachidonic acid & Leptin receptor. The author has an hindex of 10, co-authored 13 publications receiving 766 citations.
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Journal ArticleDOI
Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status.
Sabine Violette,Laurent Poulain,Elisabeth Dussaulx,Dominique Pepin,Anne-Marie Faussat,Jean Chambaz,Jean-Marc Lacorte,Cathy Staedel,Thécla Lesuffleur +8 more
TL;DR: The ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell lines differing in p53 and bax status is reported and high levels of anti‐apoptotic Bcl‐2 and B cl‐xL proteins combined with a low level of Bax were correlated to high 5‐FU resistance of wild‐type p53 cell lines.
Journal ArticleDOI
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.
Tinh-Hai Collet,Tinh-Hai Collet,Béatrice Dubern,Béatrice Dubern,Jacek Mokrosinski,Connors H,Julia M. Keogh,Edson Mendes de Oliveira,Elana Henning,Christine Poitou-Bernert,Christine Poitou-Bernert,Jean-Michel Oppert,Jean-Michel Oppert,Patrick Tounian,Patrick Tounian,Florence Marchelli,Rohia Alili,Rohia Alili,Johanne Le Beyec,Johanne Le Beyec,Dominique Pepin,Jean Marc Lacorte,Jean Marc Lacorte,Andrew Gottesdiener,Rebecca Bounds,Shubh D. Sharma,Cathy Folster,Bart Henderson,Stephen O'Rahilly,Elizabeth Stoner,Keith Gottesdiener,Brandon L. Panaro,Brandon L. Panaro,Roger D. Cone,Roger D. Cone,Karine Clément,Karine Clément,I. Sadaf Farooqi,Lex H.T. Van der Ploeg +38 more
TL;DR: It is shown that Setmelanotide is significantly more potent at MC4R than the endogenous ligand alpha-melanocyte stimulating hormone and can disproportionally rescue signaling by a subset of severely impairedMC4R mutants.
Journal ArticleDOI
Essential fatty acids interconversion in the human fetal liver.
TL;DR: The data suggest that arachidonic acid is supplied to the fetus through a preferential transfer across the placenta via delta 5- and delta 6-desaturase activities in fetal liver microsomes.
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Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery
Jérôme Alexandre Denis,Jérôme Alexandre Denis,Alexia Patroni,Erell Guillerm,Dominique Pepin,Naoual Benali-Furet,Janine Wechsler,Gilles Manceau,Maguy Bernard,Florence Coulet,Annette K. Larsen,Mehdi Karoui,Jean-Marc Lacorte,Jean-Marc Lacorte +13 more
TL;DR: It is suggested that it is feasible to detect KRAS mutations in CTCs from blood samples of CRC patients which are predictive for those found in the tumor.
Journal ArticleDOI
Seven Novel Deleterious LEPR Mutations Found in Early-Onset Obesity: a ΔExon6–8 Shared by Subjects From Reunion Island, France, Suggests a Founder Effect
Hélène Huvenne,Johanne Le Beyec,Johanne Le Beyec,Dominique Pepin,Rohia Alili,Patricia Pigeon Kherchiche,Erwan Jeannic,Marie-Laure Frelut,Jean-Marc Lacorte,Marc Nicolino,Amélie Viard,Martine Laville,Séverine Ledoux,Patrick Tounian,Christine Poitou,Christine Poitou,Béatrice Dubern,Karine Clément,Karine Clément +18 more
TL;DR: Among seven newly discovered LEPR mutations in this French obese population, a LEPR frameshift mutation shared by six subjects from Reunion Island suggests a founder effect in this Indian Ocean island with high prevalence of obesity and supports a recommendation for systematic screening for this mutation in morbidly obese subjects in this population.