D
Donald M. Bers
Researcher at University of California, Davis
Publications - 607
Citations - 57349
Donald M. Bers is an academic researcher from University of California, Davis. The author has contributed to research in topics: Ryanodine receptor & Ca2+/calmodulin-dependent protein kinase. The author has an hindex of 118, co-authored 570 publications receiving 52757 citations. Previous affiliations of Donald M. Bers include University of Maryland, Baltimore & Loyola University Medical Center.
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Journal ArticleDOI
Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase.
TL;DR: PLM phosphorylation at either Ser63 or Ser68 is both necessary and sufficient for completely relieving the PLM-induced NKA inhibition.
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CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy.
Senka Ljubojevic-Holzer,Senka Ljubojevic-Holzer,Anthony W. Herren,Natasa Djalinac,Julia Voglhuber,Stefano Morotti,Michael Holzer,Brent M. Wood,Mahmoud Abdellatif,Ingrid Matzer,Michael Sacherer,Snjezana Radulovic,M. Wallner,Milan Ivanov,Stefan Wagner,Samuel Sossalla,Samuel Sossalla,Dirk von Lewinski,Burkert Pieske,Joan Heller Brown,Simon Sedej,Simon Sedej,Julie Bossuyt,Donald M. Bers +23 more
TL;DR: It is concluded that in early TAC perinuclear CaMKIIδC activation promotes adaptive increases in myocyte Ca2+ transients and nuclear transcriptional responses but that chronic progression of this nuclear Ca2-CaMKII δC axis contributes to eccentric hypertrophy and HF.
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Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility.
Yong Ji,Wen Zhao,Bailing Li,Jaime DeSantiago,Eckard Picht,Marcia A. Kaetzel,Jo El J. Schultz,Evangelia G. Kranias,Donald M. Bers,John R. Dedman +9 more
TL;DR: It is demonstrated that inhibition of SR CaMKII activity at the LSR results in alterations in cardiac contractility and Ca2+ handling in TG hearts.
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Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.
Scott A. Tiscione,Oscar Vivas,Kenneth S. Ginsburg,Donald M. Bers,Daniel S. Ory,Luis Fernando Santana,Rose E. Dixon,Eamonn J. Dickson +7 more
TL;DR: A molecular mechanism that links lysosomal cholesterol export with the regulation of key intracellular Ca2+ signaling pathways to influence synaptic architecture in health and neurodegenerative NPC1 disease is reported.
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Na/Ca exchange function in intact ventricular myocytes.
TL;DR: Three issues in intact ventricular myocytes that specifically relate to the role of Na/Ca exchange (NCX) current under physiological conditions are addressed and it is shown that outward and inward INCX can be activated dynamically by changing [Ca]i over the physiological range.