L
Luis Fernando Santana
Researcher at University of California, Davis
Publications - 118
Citations - 9683
Luis Fernando Santana is an academic researcher from University of California, Davis. The author has contributed to research in topics: Voltage-dependent calcium channel & Myocyte. The author has an hindex of 49, co-authored 105 publications receiving 8806 citations. Previous affiliations of Luis Fernando Santana include University of Washington & Sao Paulo State University.
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Journal ArticleDOI
Relaxation of arterial smooth muscle by calcium sparks
Mark T. Nelson,Heping Cheng,Michael Rubart,Luis Fernando Santana,Adrian D. Bonev,Harm J. Knot,W. J. Lederer +6 more
TL;DR: KCa channels activated by Ca2+ sparks appeared to hyperpolarize and dilate pressurized myogenic arteries because ryanodine and thapsigargin depolarized and constricted these arteries to an extent similar to that produced by blockers of KCa channels.
Journal ArticleDOI
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.
Ana María Gómez,Héctor H. Valdivia,Heping Cheng,Miriam R. Lederer,Luis Fernando Santana,Mark B. Cannell,S. A. McCune,Ruth A. Altschuld,W. J. Lederer +8 more
TL;DR: The same defect in EC coupling that develops during hypertrophy may contribute to heart failure when compensatory mechanisms fail because it appears to reside in a change in the relation between SR calcium-release channels and sarcolemmal calcium channels.
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Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure
Dao-Fu Dai,Simon C. Johnson,Jason J. Villarin,Michael T. Chin,Madeline Nieves-Cintrón,Tony Chen,David J. Marcinek,Gerald W. Dorn,Y. James Kang,Tomas A. Prolla,Luis Fernando Santana,Peter S. Rabinovitch +11 more
TL;DR: The data indicate the critical role of mitochondrial ROS in cardiac hypertrophy and failure and support the potential use of mitochondrial-targeted antioxidants for prevention and treatment of hypertensive cardiomyopathy.
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Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging
Dao-Fu Dai,Luis Fernando Santana,Marc Vermulst,Daniela M. Tomazela,Mary J. Emond,Michael J. MacCoss,Katherine A. Gollahon,George M. Martin,Lawrence A. Loeb,Warren C. Ladiges,Peter S. Rabinovitch +10 more
TL;DR: It is shown that cardiac aging in the mouse closely recapitulates human aging and demonstrates the critical role of mitochondrial reactive oxygen species in cardiac aging and the impact of cardiac aging on survival.
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Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane
TL;DR: A new model for NGF-mediated hyperalgesia is proposed in which physical coupling of TRPV1 and PI3K in a signal transduction complex facilitates trafficking of TRpV1 to the plasma membrane.