Journal ArticleDOI
Treatment of Traumatic Brain Injury with Moderate Hypothermia
Donald W. Marion,Louis E. Penrod,Sheryl F. Kelsey,Walter Obrist,Patrick M. Kochanek,Alan M. Palmer,Stephen R. Wisniewski,Steven T. DeKosky +7 more
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TLDR
A randomized, controlled trial compared the effects of moderate hypothermia and normothermia in 82 patients with severe closed head injuries and found thatHypothermia may limit some of the deleterious metabolic responses of traumatic brain injury.Abstract:
Early reports of therapeutic hypothermia for severe traumatic brain injury can be traced back to the first half of the 20th century. It is only within the last two decades that clinical studies have demonstrated that therapeutic moderate hypothermia for brief durations can improve patient outcomes following brain injury. The historical background, recent clinical experience, and mechanisms of action of moderate hypothermia are reviewed.read more
Citations
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Journal ArticleDOI
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
A. B Ernard,Imothy W. G Ray,D. B Uist,M. J Ones,W Illiam S Ilvester,G Eoff G Utteridge,K Aren S Mith +6 more
TL;DR: This randomized, controlled trial compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest to survive to hospital discharge and be discharged to home or to a rehabilitation facility.
Journal ArticleDOI
Cooling for newborns with hypoxic ischaemic encephalopathy.
TL;DR: Although two small randomised controlled trials demonstrated neither evidence of benefit or harm, current evidence is inadequate to assess either safety or efficacy of therapeutic hypothermia in newborn infants with hypoxic ischaemic encephalopathy.
Journal ArticleDOI
The ICH Score A Simple, Reliable Grading Scale for Intracerebral Hemorrhage
J. Claude Hemphill,David C. Bonovich,Lavrentios Besmertis,Geoffrey T. Manley,S. Claiborne Johnston +4 more
TL;DR: The authors in this article reported that ICH constitutes 10% to 15% of all strokes and remains without a treatment of proven benefit, despite several existing outcome prediction models for ICH.
Journal ArticleDOI
Lack of effect of induction of hypothermia after acute brain injury.
Guy L. Clifton,Emmy R. Miller,Sung C. Choi,Harvey S. Levin,Stephen R. McCauley,Kenneth R. Smith,Jan Paul Muizelaar,Franklin C. Wagner,Donald W. Marion,Thomas G. Luerssen,Randall M. Chesnut,Michael L. Schwartz +11 more
TL;DR: Treatment with hypothermia, with the body temperature reaching 33 degrees C within eight hours after injury, is not effective in improving outcomes in patients with severe brain injury.
Journal ArticleDOI
Clinical trials in head injury
Raj K. Narayan,Mary Ellen Michel,Beth Ansell,Alex Baethmann,Anat Biegon,Michael B. Bracken,M. Ross Bullock,Sung C. Choi,Guy L. Clifton,Charles F. Contant,William M. Coplin,W. Dalton Dietrich,Jamshid Ghajar,Sean M. Grady,Robert G. Grossman,Edward D. Hall,William Heetderks,David A. Hovda,Jack Jallo,Russell L. Katz,Nachshon Knoller,Patrick M. Kochanek,Andrew I R Maas,Jeannine Majde,Donald W. Marion,A Marmarou,Lawrence F. Marshall,Tracy K. McIntosh,Emmy Miller,Noel Mohberg,J. Paul Muizelaar,Lawrence H. Pitts,Peter Quinn,Gad Riesenfeld,Claudia S. Robertson,Kenneth I. Strauss,Graham M. Teasdale,Nancy Temkin,Ronald F. Tuma,Charles E. Wade,Michael D. Walker,Michael Weinrich,John Whyte,Jack E. Wilberger,A. Byron Young,Lorraine Yurkewicz +45 more
TL;DR: The pathomechanisms of traumatic brain damage, based upon their clinical importance, are discussed and a uniform strategic approach for evaluation of potentially interesting new compounds in clinical trials, to ameliorate outcome in patients with severe head injury, is proposed.
References
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Journal ArticleDOI
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Graham M. Teasdale,Bryan Jennett +1 more
TL;DR: A clinical scale has been evolved for assessing the depth and duration of impaired consciousness and coma that facilitates consultations between general and special units in cases of recent brain damage, and is useful also in defining the duration of prolonged coma.
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TL;DR: A critical question has been why brain, more than mostother tissues, is so vulnerable to hypoxic-ischemic insults, and at least some of this special vulnerability may be accounted for by the central neurotoxicity of the endogenous excitatory
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Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury
Raul Busto,W. Dalton Dietrich,Mordecai Y.-T. Globus,I. Valdes,Peritz Scheinberg,Myron D. Ginsberg +5 more
TL;DR: Results demonstrate that rectal temperature unreliably reflects brain temperature during ischemia, and that despite severe depletion of brain energy metabolites at all temperatures, small increments of intraischemic brain temperature markedly accentuate histopathological changes following 3-day survival.
Journal ArticleDOI
Cell Damage in the Brain: A Speculative Synthesis
TL;DR: In this article, it was shown that the clinically most important conditions leading to brain cell death are those associated with cerebrovascul ar dise ase, particularly stroke, and with head trauma.
Journal ArticleDOI
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
TL;DR: Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site, which contributes to delayed tissue damage after brain trauma.