D
Donatella Macchia
Researcher at University of Florence
Publications - 52
Citations - 4884
Donatella Macchia is an academic researcher from University of Florence. The author has contributed to research in topics: Immunoglobulin E & T cell. The author has an hindex of 25, co-authored 48 publications receiving 4792 citations.
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Journal ArticleDOI
Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.
G Del Prete,M De Carli,C Mastromauro,Roberta Biagiotti,Donatella Macchia,P. Falagiani,Mario Ricci,Sergio Romagnani +7 more
TL;DR: It is demonstrated that T cells with stable Th1 or Th2 functional pattern exist not only in mice but also in humans and suggest that in the course of natural immunization certain infectious agents preferentially expand T cell subsets with stable and definite profile of cytokine production.
Journal Article
IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.
G Del Prete,Enrico Maggi,Paola Parronchi,I Chretien,A Tiri,Donatella Macchia,Mario Ricci,Jacques F. Banchereau,J E de Vries,Sergio Romagnani +9 more
TL;DR: IL-4 is an essential mediator for the IgE synthesis induced in vitro by human TCC and their SUP in the absence of a polyclonal activator, whereas IFN-gamma seems to exert a negative regulatory effect on the production of IgE.
Journal ArticleDOI
Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.
Paola Parronchi,Donatella Macchia,Marie-Pierre Piccinni,Priscilla Biswas,C Simonelli,Enrico Maggi,Mario Ricci,Aftab A. Ansari,Sergio Romagnani +8 more
TL;DR: It is demonstrated that most allergen-specific helper T cells in atopic individuals are able to produce high amounts of IL-4 (and IL-5), but no IFN-gamma, which may explain why allergens induce production of IgE antibodies and increase eosinophils.
Journal ArticleDOI
Infection of peripheral mononuclear blood cells by hepatitis C virus
Anna Linda Zignego,Anna Linda Zignego,Donatella Macchia,Monica Monti,Valérie Thiers,Marcello Mazzetti,Marco Foschi,Enrico Maggi,Sergio Romagnani,Paolo Gentilini,Christian Bréchot,Christian Bréchot +11 more
TL;DR: The results indicate that HCV infect blood mononuclear cells, thus suggesting that this cellular tropism may play a role in HCV infection.
Journal Article
IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.
Paola Parronchi,M De Carli,Roberto Manetti,C Simonelli,S. Sampognaro,Marie-Pierre Piccinni,Donatella Macchia,Enrico Maggi,G Del Prete,Sergio Romagnani +9 more
TL;DR: It is demonstrated that the addition of IFN (alpha and gamma) or IL-4 in bulk cultures before cloning may influence not only the cytokine profile of human CD4+ T cell clones but also their cytolytic potential.