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Roberto Manetti
Researcher at University of Florence
Publications - 88
Citations - 11980
Roberto Manetti is an academic researcher from University of Florence. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 47, co-authored 80 publications receiving 11707 citations.
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Journal ArticleDOI
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
Roberto Manetti,Paola Parronchi,Maria Grazia Giudizi,Marie-Pierre Piccinni,Enrico Maggi,Giorgio Trinchieri,Sergio Romagnani +6 more
TL;DR: IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses.
Journal ArticleDOI
Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.
Mariagrazia Pizza,[No Value] Scarlato,Masignani,Marzia Monica Giuliani,Beatrice Aricò,Maurizio Comanducci,Gary T. Jennings,L Baldi,Erika Bartolini,Barbara Capecchi,CL Galeotti,Enrico Luzzi,Roberto Manetti,Elisa Marchetti,Marirosa Mora,Sandra Nuti,Giulio Ratti,Laura Santini,Silvana Savino,Maria Scarselli,E Storni,PJ Zuo,M Broeker,E Hundt,B Knapp,E Blair,Tanya Mason,Hervé Tettelin,Derek W. Hood,AC Jeffries,Nigel J. Saunders,Dan M. Granoff,J. C. Venter,E R Moxon,Guido Grandi,Rino Rappuoli +35 more
TL;DR: The entire genome sequence of a virulent serogroup B strain was used to identify vaccine candidates and allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans.
Journal Article
Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones.
Marie-Pierre Piccinni,Maria Grazia Giudizi,Roberta Biagiotti,Lucio Beloni,L Giannarini,S. Sampognaro,Paola Parronchi,Roberto Manetti,Francesco Annunziato,Claudia Livi +9 more
TL;DR: Results indicate that P can favor the development of Th cells producing Th2-type cytokines and is an inducer of both transient IL-4 production and CD30 expression in established Th1 cells.
Journal Article
Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.
Enrico Maggi,Paola Parronchi,Roberto Manetti,C Simonelli,Marie-Pierre Piccinni,Francesco Santoni Rugiu,M De Carli,Mario Ricci,Sergio Romagnani +8 more
TL;DR: The data suggest that the presence or the absence of IL-4 and IFN-gamma in bulk cultures of PBMC before cloning may have strong regulatory effects on the in vitro development of human CD4+ T cells into Th1 or Th2 clones.
Journal ArticleDOI
Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells
Enrico Maggi,Marcello Mazzetti,Adriana Ravina,Francesco Annunziato,Marco De Carli,Marie-Pierre Piccinni,Roberto Manetti,Maurizio Carbonari,Anna Maria Pesce,Gianfranco Del Prete,Sergio Romagnani +10 more
TL;DR: The results suggest that HIV does not induce a definite TH1 to TH2 switch, but can favor a shift to the TH0 phenotype in response to recall antigens, and preferentially replicates in CD4+ T cells producing TH2-type cytokines (TH2 and TH0).