M
Marie-Pierre Piccinni
Researcher at University of Florence
Publications - 103
Citations - 10612
Marie-Pierre Piccinni is an academic researcher from University of Florence. The author has contributed to research in topics: T cell & Cytokine. The author has an hindex of 44, co-authored 100 publications receiving 10122 citations.
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Journal ArticleDOI
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
Roberto Manetti,Paola Parronchi,Maria Grazia Giudizi,Marie-Pierre Piccinni,Enrico Maggi,Giorgio Trinchieri,Sergio Romagnani +6 more
TL;DR: IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses.
Journal Article
Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones.
Marie-Pierre Piccinni,Maria Grazia Giudizi,Roberta Biagiotti,Lucio Beloni,L Giannarini,S. Sampognaro,Paola Parronchi,Roberto Manetti,Francesco Annunziato,Claudia Livi +9 more
TL;DR: Results indicate that P can favor the development of Th cells producing Th2-type cytokines and is an inducer of both transient IL-4 production and CD30 expression in established Th1 cells.
Journal Article
Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.
Enrico Maggi,Paola Parronchi,Roberto Manetti,C Simonelli,Marie-Pierre Piccinni,Francesco Santoni Rugiu,M De Carli,Mario Ricci,Sergio Romagnani +8 more
TL;DR: The data suggest that the presence or the absence of IL-4 and IFN-gamma in bulk cultures of PBMC before cloning may have strong regulatory effects on the in vitro development of human CD4+ T cells into Th1 or Th2 clones.
Journal ArticleDOI
Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions.
Marie-Pierre Piccinni,Lucio Beloni,Claudia Livi,Enrico Maggi,Gianfranco Scarselli,Sergio Romagnani +5 more
TL;DR: It is shown that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated byIFN-γ and IFN-α, and a decreased production of LIF, IL- 4 and IL-10 by decidual T cells of women with unexplained recurrent abortions is shown.
Journal ArticleDOI
Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.
Paola Parronchi,Donatella Macchia,Marie-Pierre Piccinni,Priscilla Biswas,C Simonelli,Enrico Maggi,Mario Ricci,Aftab A. Ansari,Sergio Romagnani +8 more
TL;DR: It is demonstrated that most allergen-specific helper T cells in atopic individuals are able to produce high amounts of IL-4 (and IL-5), but no IFN-gamma, which may explain why allergens induce production of IgE antibodies and increase eosinophils.