D
Dong-Ming Su
Researcher at University of North Texas Health Science Center
Publications - 58
Citations - 2775
Dong-Ming Su is an academic researcher from University of North Texas Health Science Center. The author has contributed to research in topics: Thymic involution & T cell. The author has an hindex of 25, co-authored 53 publications receiving 2342 citations. Previous affiliations of Dong-Ming Su include University of Texas at Tyler & University of Texas Health Science Center at Tyler.
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Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis.
TL;DR: Examination of the effects of chemopreventive agents on the surface expression of programmed death-1-ligand 1, a negative regulator of T cell anti-tumor immunity, reveals a potential link between chemotherapy and cancer immunoresistance.
Journal ArticleDOI
γ-Secretase inhibitors repress thymocyte development
Brandon Hadland,Nancy R. Manley,Dong-Ming Su,Gregory D. Longmore,Chad L. Moore,Michael S. Wolfe,Michael S. Wolfe,Eric H. Schroeter,Raphael Kopan +8 more
TL;DR: It is shown that application of γ-secretase inhibitors to fetal thymus organ cultures interferes with T cell development in a manner consistent with loss or reduction of Notch1 function, and this system presents a system in which rapid evaluation of ιsecretase-targeted pharmaceuticals for their ability to inhibit Notch activity can be performed in a relevant context.
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Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
TL;DR: How T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer is described.
Journal Article
Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma
TL;DR: Previous and most recent evidence is emphasized suggesting that early programming of the thymus, sexual dimorphism, and the efficiency of specific T-cell progenitors and theThymic microenvironment are all crucial determinants of immune activity from early life through advanced ages.
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A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation.
TL;DR: In contrast to thymi in mice with the null allele, the Foxn1Δ/Δ thymus promoted T cell development, but with specific defects at both the double-negative and double-positive stages.