Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
TLDR
How T cell adaptive immunity mediates inflammaging and plays a crucial role in the progression of age-related neurological and cardiovascular diseases, as well as cancer is described.Citations
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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
TL;DR: Coppe et al. as mentioned in this paper showed that human cells induced to senesce by genotoxic stress secrete myriad factors associated with inflammation and malignancy, including interleukin (IL)-6 and IL-8.
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Immunosenescence: a key player in cancer development.
TL;DR: The characteristics of immunosenescence and its impact on malignant tumors and immunotherapy are highlighted, especially the future directions of tumor treatment through senescence-focused strategies.
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Hallmarks of T cell aging.
María Mittelbrunn,Guido Kroemer +1 more
TL;DR: Mittelbrunn and Kroemer as mentioned in this paper proposed ten molecular hallmarks to represent common denominators of T cell aging, which are grouped into four primary hallmarks (thymic involution, mitochondrial dysfunction, genetic and epigenetic alterations, and loss of proteostasis) and four secondary hallmarks(reduction of the TCR repertoire, naive memory imbalance, T cell senescence, and lack of effector plasticity).
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Zinc and COVID-19: Basis of Current Clinical Trials.
Amit Pal,Rosanna Squitti,Mario Picozza,Anil Pawar,Mauro Rongioletti,Atanu Kumar Dutta,Sibasish Sahoo,Kalyan Goswami,Praveen Sharma,Rajendra Prasad +9 more
TL;DR: This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against CO VID-19, and ongoing COVID-19 clinical trials using zinc.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Regulatory T Cells and Immune Tolerance
TL;DR: The cellular and molecular basis of Treg development and function is revealed and dysregulation of T Regs in immunological disease is implicates.