D
Donna E. Davies
Researcher at University of Southampton
Publications - 265
Citations - 19127
Donna E. Davies is an academic researcher from University of Southampton. The author has contributed to research in topics: Asthma & Epidermal growth factor. The author has an hindex of 67, co-authored 253 publications receiving 17322 citations. Previous affiliations of Donna E. Davies include National Oceanography Centre, Southampton & École normale supérieure de Lyon.
Papers
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Journal ArticleDOI
The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma.
TL;DR: A fuller comprehension of the actions of transforming growth factor-β, and its interaction with other signalling pathways, such as the epidermal growth factor receptor signalling cascade, may enable development of therapies that control airway remodelling where there is an unmet clinical need.
Journal ArticleDOI
Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.
Stephen T. Holgate,John W. Holloway,Susan J. Wilson,Fabio Bucchieri,Sarah M. Puddicombe,Donna E. Davies +5 more
TL;DR: The observation that structural changes in the airways in children at or before the onset of asthma occurs irrespective of inflammation might suggest that premodeling is required before Th-2 inflammatory responses can be sustained.
Journal ArticleDOI
The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.
Ratko Djukanovic,Tim Harrison,Sebastian L. Johnston,Flic Gabbay,Peter A. B. Wark,Neil C. Thomson,Robert Niven,Dave Singh,Helen K. Reddel,Donna E. Davies,Richard J Marsden,Christine B. Boxall,Sarah Dudley,Vincent Plagnol,Stephen T. Holgate,Phillip Monk +15 more
TL;DR: It is suggested that inhaled IFN-β is a potential treatment for virus-induced deteriorations of asthma in difficult-to-treat people with asthma and supports the need for further, adequately powered, trials in this population.
Journal ArticleDOI
The Role of the Airway Epithelium and its Interaction with Environmental Factors in Asthma Pathogenesis
TL;DR: Viewing asthma primarily as an epithelial disease with adoption of a chronic wound scenario also provides a route to airway wall remodeling and the varying asthma phenotypes over the life course.
Journal ArticleDOI
Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease
Stefan Pierrou,Per Broberg,Rory A. O'Donnell,Krzysztof Pawłowski,Robert Virtala,Eva Lindqvist,Audrey Richter,Susan J. Wilson,Gilbert Angco,Sebastian Möller,Håkan Bergstrand,Witte Koopmann,Elisabet Wieslander,Per Erik Strömstedt,Stephen T. Holgate,Donna E. Davies,Johan Lund,Ratko Djukanovic +17 more
TL;DR: Gene set enrichment analysis showed that pathways involved in oxidant/antioxidant responses were among the most differentially expressed gene pathways in smoking individuals, with further differences seen in COPD.