D
Donna E. Davies
Researcher at University of Southampton
Publications - 265
Citations - 19127
Donna E. Davies is an academic researcher from University of Southampton. The author has contributed to research in topics: Asthma & Epidermal growth factor. The author has an hindex of 67, co-authored 253 publications receiving 17322 citations. Previous affiliations of Donna E. Davies include National Oceanography Centre, Southampton & École normale supérieure de Lyon.
Papers
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Journal ArticleDOI
Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development
Hans Michael Haitchi,Hajime Yoshisue,Anna Ribbene,Susan J. Wilson,John W. Holloway,Fabio Bucchieri,Neil A. Hanley,David I. Wilson,G. Zummo,Stephen T. Holgate,Donna E. Davies +10 more
TL;DR: Chronological regulation of CBE1/Cbe1 expression during pulmonary differentiation suggests involvement in ciliogenesis, with an additional role during early lung development.
Journal ArticleDOI
Application of functional genomics to study of inflammatory airways disease
TL;DR: The development of asthma requires combined inheritance of genes which alter the immune cell response to the environment and, at the same time, render the airways structural and neural regulation susceptible to injury caused by inflammation.
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A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis
Asif Shaffiq,Hans Michael Haitchi,Yun Yung Pang,Abdullah A. Alangari,Abdullah A. Alangari,Mark Jones,Ben G. Marshall,Peter H. Howarth,Peter H. Howarth,Donna E. Davies,Donna E. Davies,Katherine M.A. O'Reilly +11 more
TL;DR: A soluble form of ADAM33 (sADAM33) has been identified in the bronchoalveolar lavage fluid of asthmatic patients, and its levels inversely correlate with lung function.
Journal ArticleDOI
The Epithelial-Mesenchymal Trophic Unit in Asthma
Sarah M. Puddicombe,R Polosa,Audrey Richter,Peter H. Howarth,Donna E. Davies,Stephen T. Holgate +5 more
Journal ArticleDOI
Epithelial-mesenchymal interactions in the pathogenesis of asthma
Stephen T. Holgate,Donna E. Davies,Sarah M. Puddicombe,Audrey Richter,Peter M. Lackie,James L. Lordan,Peter H. Howarth +6 more
TL;DR: It is proposed that impaired epithelial repair cooperates with the T(H)2 environment to shift the set point for communication within the trophic unit and leads to myofibroblast activation, excessive matrix deposition, and production of mediators that propagate and amplify the remodeling responses throughout the airway wall.