D
Donna E. Davies
Researcher at University of Southampton
Publications - 265
Citations - 19127
Donna E. Davies is an academic researcher from University of Southampton. The author has contributed to research in topics: Asthma & Epidermal growth factor. The author has an hindex of 67, co-authored 253 publications receiving 17322 citations. Previous affiliations of Donna E. Davies include National Oceanography Centre, Southampton & École normale supérieure de Lyon.
Papers
More filters
Journal ArticleDOI
CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death
Anna Maria Merendino,Fabio Bucchieri,Rosalia Gagliardo,Arezoo Daryadel,Flora Pompeo,Giuseppina Chiappara,Roberta Santagata,Vincenzo Bellia,Sabrina David,Felicia Farina,Donna E. Davies,Hans-Uwe Simon,Antonio M. Vignola +12 more
TL;DR: A novel role for CD40 is demonstrated as a regulator of epithelial cell survival against oxidant stress and an endogenous inhibitory pathway of caspase-independent cell death is identified, for the first time, is identified.
Journal ArticleDOI
Two newly established cell lines derived from the same colonic adenocarcinoma exhibit differences in EGF-receptor ligand and adhesion molecule expression.
Nicola Solic,Jane E. Collins,Audrey Richter,Susan J. Holt,Ian G. Campbell,Peter Alexander,Donna E. Davies +6 more
TL;DR: Two morphologically distinct cell lines, GP2d and GP5d, derived from the same adenocarcinoma of the colon, have been established and characterised, indicating separation of growth and morphological responses to EGF.
Journal ArticleDOI
Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells
Maaike de Vries,Maaike de Vries,Natalie P. Smithers,Peter H. Howarth,Martijn C. Nawijn,Donna E. Davies +5 more
TL;DR: It is hypothesised that inhibition of Pim1 kinase activity in virally infected PBECs would enhance the onset of cell death, resulting in reduced viral replication.
Journal ArticleDOI
Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus.
Matthew Loxham,David E. Smart,Nicole Bedke,Natalie P. Smithers,Irene Filippi,Irene Filippi,Cornelia Blume,Emily J. Swindle,Kamran Tariq,Peter H. Howarth,Stephen T. Holgate,Donna E. Davies +11 more
TL;DR: A novel mechanism whereby allergenic proteases cleave CX3CL1 from the apical epithelial surface to yield a biologically active product is identified, which may contribute to synergy between allergen exposure and RV infection in triggering asthma exacerbations and airway remodeling.
Journal ArticleDOI
Ligand-induced translocation of epidermal growth factor receptor to the nucleus of NR6/HER fibroblasts is serum dependent.
TL;DR: The results indicate that translocation of EGF-R to the nucleus is a controlled process and they suggest that E GF-R may directly influence nuclear function.