D
Donna E. Davies
Researcher at University of Southampton
Publications - 265
Citations - 19127
Donna E. Davies is an academic researcher from University of Southampton. The author has contributed to research in topics: Asthma & Epidermal growth factor. The author has an hindex of 67, co-authored 253 publications receiving 17322 citations. Previous affiliations of Donna E. Davies include National Oceanography Centre, Southampton & École normale supérieure de Lyon.
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Journal ArticleDOI
Asthmatic Bronchial Epithelium is More Susceptible to Oxidant — Induced Apoptosis (Introduced by ST Holgate)
Donna E. Davies,Fabio Bucchieri,James L. Lordan,Peter H. Howarth,Ratko Djukanovic,S. T. Holgate +5 more
TL;DR: The data indicate that the susceptibility of asthmatic bronchial epithelium to oxidants is greater than normal, which may contribute to the rising trends in asthma associated with air pollution and diets low in antioxidants.
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The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: Implications for airway remodeling in asthma
Ilaria Puxeddu,Yun Yun Pang,Anna Harvey,Hans Michael Haitchi,Ben Nicholas,Hajime Yoshisue,Domenico Ribatti,Geraldine F. Clough,Robert M. Powell,Gillian Murphy,Neil A. Hanley,David I. Wilson,Peter H. Howarth,Stephen T. Holgate,Donna E. Davies +14 more
TL;DR: It is shown that the purified catalytic domain of ADAM33, but not its inactive mutant, causes rapid induction of endothelial cell differentiation in vitro, and neovascularization ex vivo and in vivo, and that TGF-beta(2) enhances sADAM33 release from cells overexpressing full-length ADAM 33 and that this truncated form is biologically active.
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The genetics of asthma: ADAM33 as an example of a susceptibility gene
Stephen T. Holgate,Youwen Yang,Hans Michael Haitchi,Robert M. Powell,John W. Holloway,Hajime Yoshisue,Yun Yun Pang,Julie A. Cakebread,Donna E. Davies +8 more
TL;DR: Its recent association with chronic obstructive pulmonary disease as well as with asthma and lung development points to functions relating to airway wall modeling and remodeling as a general morphogenetic repair gene rather than being restricted to asthma.
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Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis
Liudi Yao,Franco Conforti,Charlotte Hill,Joseph Bell,Leena Drawater,Juanjuan Li,Dian Liu,Hua Xiong,Aiman Alzetani,Serena J Chee,Ben G. Marshall,Sophie V. Fletcher,David C. Hancock,Mark J. Coldwell,Xianglin Yuan,Christian H. Ottensmeier,Julian Downward,Jane E. Collins,Rob M. Ewing,Luca Richeldi,Luca Richeldi,Paul Skipp,Mark Jones,Donna E. Davies,Yihua Wang,Yihua Wang +25 more
TL;DR: Evidence is provided that ZEB1-mediated EMT in human alveolar epithelial type II (ATII) cells contributes to the development of lung fibrosis by paracrine signalling to underlying fibroblasts by controlling the expression of tissue plasminogen activator.
Journal ArticleDOI
IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts.
Allison-Lynn Andrews,Tosia Nasir,Fabio Bucchieri,John W. Holloway,Stephen T. Holgate,Donna E. Davies +5 more
TL;DR: It appears that IL-13Ralpha2 might be a powerful suppressor of TH2-mediated responses and thus represents a potential therapeutic target for the treatment of asthma.