D
Donna Rennick
Researcher at Schering-Plough
Publications - 83
Citations - 19594
Donna Rennick is an academic researcher from Schering-Plough. The author has contributed to research in topics: Complementary DNA & Interleukin 4. The author has an hindex of 42, co-authored 83 publications receiving 18887 citations.
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Journal ArticleDOI
Interleukin-10-deficient mice develop chronic enterocolitis
TL;DR: The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
Journal ArticleDOI
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Birgit Oppmann,Robin Lesley,Bianca Blom,Jackie C. Timans,Yuming Xu,Brisdell Hunte,Felix Vega,Nancy Yu,Jing Wang,Komal Singh,Francesca Zonin,Elena Vaisberg,Tatyana Churakova,Man ru Liu,Daniel M. Gorman,Janet Wagner,Sandra Zurawski,Yong-Jun Liu,John S. Abrams,Kevin W. Moore,Donna Rennick,Rene de Waal-Malefyt,Charles H. Hannum,J. Fernando Bazan,Robert A. Kastelein +24 more
TL;DR: Human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells and induces strong proliferation of mouse memory T cells.
Journal ArticleDOI
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
David C. Yen,Jeanne Cheung,Heleen Scheerens,Frederique M. Poulet,Terrill K. McClanahan,Brent S. McKenzie,Melanie A. Kleinschek,Alexander Owyang,Jeanine D. Mattson,Wendy M. Blumenschein,Erin Murphy,Manjiri Sathe,Daniel J. Cua,Robert A. Kastelein,Donna Rennick +14 more
TL;DR: This study shows that in these models, IL-23 is essential for manifestation of chronic intestinal inflammation, whereas IL-12 is not, and a critical target of IL- 23 is a unique subset of tissue-homing memory T cells, which are specifically activated by IL-21 to produce the proinflammatory mediators IL-17 and IL-6.
Journal ArticleDOI
IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells
Stefan Pflanz,Jackie C. Timans,Jeanne Cheung,Rency Rosales,Holger Kanzler,Jonathan M. Gilbert,Linda Hibbert,Tatyana Churakova,Marilyn Travis,Elena Vaisberg,Wendy M. Blumenschein,Jeanine D. Mattson,Janet Wagner,Wayne To,Sandra Zurawski,Terrill K. McClanahan,Daniel M. Gorman,J. Fernando Bazan,Rene de Waal Malefyt,Donna Rennick,Robert A. Kastelein +20 more
TL;DR: A new heterodimeric cytokine termed IL-27 is described that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL- 12p35-related polypeptide and drives rapid clonal expansion of naive but not memory CD4(+) T cells.
Journal ArticleDOI
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
Christi L. Parham,Madaline Chirica,Jacqueline C. Timans,Elena Vaisberg,Marilyn Travis,Jeanne Cheung,Stefan Pflanz,Rebecca Zhang,Komal Singh,Felix Vega,Wayne To,Janet Wagner,Anne Marie O'Farrell,Terrill K. McClanahan,Sandra Zurawski,Charles H. Hannum,Daniel M. Gorman,Donna Rennick,Robert A. Kastelein,Rene de Waal Malefyt,Kevin W. Moore +20 more
TL;DR: A novel member of the hemopoietin receptor family is identified as a subunit of the receptor for IL-23, “IL-23R,” which pairs with IL-12Rβ1 to confer IL- 23 responsiveness on cells expressing both subunits.