D
Donny D. Licatalosi
Researcher at Case Western Reserve University
Publications - 35
Citations - 5694
Donny D. Licatalosi is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Alternative splicing & RNA-binding protein. The author has an hindex of 17, co-authored 33 publications receiving 5023 citations. Previous affiliations of Donny D. Licatalosi include Rockefeller University & University of Waterloo.
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Journal ArticleDOI
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TL;DR: A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.
Journal ArticleDOI
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Donny D. Licatalosi,Aldo Mele,John J. Fak,Jernej Ule,Melis Kayikci,Sung Wook Chi,Tyson A. Clark,Anthony C. Schweitzer,John E. Blume,Xuning Wang,Jennifer C. Darnell,Robert B. Darnell +11 more
TL;DR: A genome-wide means of mapping protein–RNA binding sites in vivo, by high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP), which revealed a large number of Nova–RNA interactions in 3′ untranslated regions, leading to the discovery that Nova regulates alternative polyadenylation in the brain.
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RNA processing and its regulation: global insights into biological networks
TL;DR: Advances in technologies for characterizing RNA populations are revealing increasingly complete descriptions of RNA regulation and complexity, yielding transcriptome-wide insights into mechanisms of RNA processing and providing new insights into molecular cell biology and disease.
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Functional interaction of yeast pre-mRNA 3' end processing factors with RNA polymerase II.
Donny D. Licatalosi,Gabrielle Geiger,Michelle Minet,Stephanie C. Schroeder,Kate Cilli,J. Bryan McNeil,David Bentley +6 more
TL;DR: The RNA polymerase II CTD is essential for 3' end cleavage of metazoan pre-mRNAs and binds3' end processing factors in vitro and genetic and biochemical interactions between the CTD and the Pcf11 subunit of the yeast cleavage/polyadenylation factor, CFIA are shown.
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Integrative Modeling Defines the Nova Splicing-Regulatory Network and Its Combinatorial Controls
Chaolin Zhang,Maria A. Frias,Aldo Mele,Matteo Ruggiu,Taesun Eom,Christina B Marney,Huidong Wang,Donny D. Licatalosi,John J. Fak,Robert B. Darnell +9 more
TL;DR: A general approach to understanding mammalian RNA regulation at the systems level is developed, using Bayesian networks to probabilistically model diverse data sets and predict the target networks of specific regulators.