Dora Kholodenko

Journal ArticleDOI

Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

- 07 Mar 1997 -

TL;DR: It is concluded that secreted A β1-40 and Aβ1-42 peptides are constitutively degraded by a metalloprotease released by microglia and other neural cells, providing a potential mechanism for the clearance of Aβ in brain tissue.

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Journal ArticleDOI

Antibody Capture of Soluble Aβ Does Not Reduce Cortical Aβ Amyloidosis in the PDAPP Mouse

Peter Seubert, +14 more

- 04 Jan 2008 -

Neurodegenerative Diseases

TL;DR: Reversing and preventing Alzheimer’s type amyloidosis is most effectively accomplished with anti-amyloid antibodies that avidly bind plaque.

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Journal ArticleDOI

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Anh P. Truong, +32 more

- 01 Nov 2010 -

Bioorganic & Medicinal Chemistry Letters

TL;DR: The efforts to design HEA BACE-1 inhibitors that are highly permeable coupled with negligible levels of permeability-glycoprotein activity culminate in producing 16 which lowers Αβ by 28% and 32% in the cortex and CSF, respectively, in the preclinical wild type Hartley guinea pig animal model.

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Journal ArticleDOI

Erratum: Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology (Proceedings of the National Academy of Science of the United States of America (February 18, 2003) 100, 4 (2023-2028))

Frederique Bard, +21 more

- 03 Aug 2004 -

Proceedings of the National Academy of S...

Journal ArticleDOI

Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration

Elizabeth F. Brigham, +24 more

- 01 Jul 2010 -

Alzheimers & Dementia

Papers

Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

Antibody Capture of Soluble Aβ Does Not Reduce Cortical Aβ Amyloidosis in the PDAPP Mouse

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Erratum: Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology (Proceedings of the National Academy of Science of the United States of America (February 18, 2003) 100, 4 (2023-2028))

Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration