D
Doris J. Doudet
Researcher at University of British Columbia
Publications - 115
Citations - 4053
Doris J. Doudet is an academic researcher from University of British Columbia. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 34, co-authored 111 publications receiving 3829 citations. Previous affiliations of Doris J. Doudet include Aarhus University Hospital & Aarhus University.
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Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration
TL;DR: Evidence of chronic neuroinflammation years after MPTP exposure is similar to that previously reported in humans and could have important implications regarding the cause of Parkinson's disease and possible approaches to therapy.
Presence of Reactive Microglia in Monkey Substantia Nigra Years after 1-Methyl-4-
TL;DR: In this paper, the authors describe the presence of reactive microglia, the accumulation of extracellular melanin, and extensive loss of dopaminergic neurons in the substantia nigra of monkeys administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 5 to 14 years before death.
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Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling
Jakob Linnet,Arne Møller,Arne Møller,Ericka Peterson,Ericka Peterson,Albert Gjedde,Albert Gjedde,Albert Gjedde,Doris J. Doudet,Doris J. Doudet,Doris J. Doudet +10 more
TL;DR: In pathological gamblers dopamine release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance, which might suggest a 'double deficit' function of dopamine in pathological gambling.
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Presynaptic dopaminergic deficits in Lesch-Nyhan disease
Monique Ernst,Alan J. Zametkin,John A. Matochik,Daisy M. Pascualvaca,Peter H. Jons,Kristina Hardy,James G. Hankerson,Doris J. Doudet,Robert M. Cohen +8 more
TL;DR: Patients with Lesch-Nyhan disease have abnormally few dopaminergic nerve terminals and cell bodies that appear to be developmental in origin, which suggests that they contribute to the characteristic neuropsychiatric manifestations of the disease.
Journal ArticleDOI
MRI and PET studies of manganese‐intoxicated monkeys
Hitoshi Shinotoh,Barry J. Snow,Kellie A. Hewitt,B. D. Pate,Doris J. Doudet,R. Nugent,Daniel P. Perl,W. Olanow,Donald B. Calne +8 more
TL;DR: Results indicate that manganese intoxication is associated with preservation of the nigrostriatal dopaminergic pathway, despite clinical evidence of parkinsonian deficits, and is consistent with the demonstrated lack of therapeutic response to levodopa.