D
Doris Wilflingseder
Researcher at Innsbruck Medical University
Publications - 95
Citations - 2663
Doris Wilflingseder is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 23, co-authored 72 publications receiving 1576 citations. Previous affiliations of Doris Wilflingseder include University of Innsbruck & University College London.
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Journal ArticleDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Thomas P. Brouwer,Douglas B. Johnson,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula Ericsson-Gonzalez,Pornpimol Charoentong,Pornpimol Charoentong,Justin M. Balko,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +25 more
TL;DR: QuanTIseq as discussed by the authors is a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data, which is extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
Posted ContentDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula I. Ericsson-Gonzalez,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +20 more
TL;DR: QuanTIseq, a deconvolution method that quantifies the densities of ten immune cell types from bulk RNA sequencing data and tissue imaging data, is developed and used to show how kinase inhibitors modulate the immune contexture and suggest that it might have predictive value for immunotherapy.
Journal Article
Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations.
Michael Gekle,Gerald Schwerdt,Ruth Freudinger,Sigrid Mildenberger,Doris Wilflingseder,Verena Pollack,Martina Dander,Herbert Schramek +7 more
TL;DR: It is shown that nanomolar concentrations of OTA lead to activation of a second member of the MAPK family, namely, c-jun amino-terminal-kinase (JNK) in MDCK-C7 cells but virtually not in MCDC-C11 cells, as determined by kinase assay and Western blot.
Journal ArticleDOI
Pseudotyping Vesicular Stomatitis Virus with Lymphocytic Choriomeningitis Virus Glycoproteins Enhances Infectivity for Glioma Cells and Minimizes Neurotropism
Alexander Muik,Inna Kneiske,Marina Werbizki,Doris Wilflingseder,Tsanan Giroglou,Oliver Ebert,Anna Kraft,Ursula Dietrich,Gert Zimmer,Stefan Momma,Dorothee von Laer +10 more
TL;DR: Compared to VSV, VSV-GP showed enhanced infectivity for brain cancer cells in vitro while sparing primary human and rat neurons in vitro and in vivo, respectively, and is thus more suitable for clinical applications, especially in the brain.
Journal ArticleDOI
HIV-1-Induced Migration of Monocyte-Derived Dendritic Cells Is Associated with Differential Activation of MAPK Pathways
Doris Wilflingseder,Brigitte Müllauer,Herbert Schramek,Zoltán Bánki,Monika Pruenster,Manfred P. Dierich,Heribert Stoiber +6 more
TL;DR: Data indicate that HIV-1 triggers a cell-specific signaling machinery, thereby manipulating DCs to migrate along a chemokine gradient, which results in productive infection of nonstimulated CD4+ cells in the Transwell system.