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Dietmar Rieder
Researcher at Innsbruck Medical University
Publications - 55
Citations - 6477
Dietmar Rieder is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 22, co-authored 46 publications receiving 3066 citations. Previous affiliations of Dietmar Rieder include Graz University of Technology.
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Journal ArticleDOI
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: The immunophenoscore was a superior predictor of response to anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) and anti-programmed cell death protein 1 (anti-PD-1) antibodies in two independent validation cohorts and may help inform cancer immunotherapy and facilitate the development of precision immuno-oncology.
Posted ContentDOI
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: Cellular characterization of the immune infiltrates revealed a role of cancer-germline antigens in spontaneous immunity and showed that tumor genotypes determine immunophenotypes and tumor escape mechanisms and a scoring scheme for the quantification termed immunophenoscore was developed.
Journal ArticleDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Thomas P. Brouwer,Douglas B. Johnson,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula Ericsson-Gonzalez,Pornpimol Charoentong,Pornpimol Charoentong,Justin M. Balko,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +25 more
TL;DR: QuanTIseq as discussed by the authors is a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data, which is extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
JournalDOI
N-acetyltransferase 8-like accelerates lipid turnover and increases energy in brown adipocytes
Ariane Pessentheiner,Helmut Josef Pelzmann,Evelyn Walenta,Martina Schweiger,Lukas N. Groschner,Wolfgang F. Graier,Dagmar Kolb,Kyosuke Uno,Toh Miyazaki,Atsumi Nitta,Dietmar Rieder,Andreas Prokesch,Juliane Gertrude Bogner-Strauß +12 more
Posted ContentDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula I. Ericsson-Gonzalez,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +20 more
TL;DR: QuanTIseq, a deconvolution method that quantifies the densities of ten immune cell types from bulk RNA sequencing data and tissue imaging data, is developed and used to show how kinase inhibitors modulate the immune contexture and suggest that it might have predictive value for immunotherapy.