K
Kevin Messacar
Researcher at University of Colorado Denver
Publications - 90
Citations - 4542
Kevin Messacar is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Acute flaccid myelitis & Medicine. The author has an hindex of 27, co-authored 79 publications receiving 3239 citations. Previous affiliations of Kevin Messacar include University of Colorado Boulder & Boston Children's Hospital.
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Journal ArticleDOI
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis
Michael R. Wilson,Hannah A. Sample,Kelsey C. Zorn,Shaun Arevalo,Guixia Yu,John Neuhaus,Scot Federman,Doug Stryke,Benjamin Briggs,Charles Langelier,Amy C. Berger,Vanja C. Douglas,S. Andrew Josephson,Felicia C. Chow,Brent D. Fulton,Joseph L. DeRisi,Jeffrey M. Gelfand,Samia N. Naccache,Jeffrey M. Bender,Jennifer Dien Bard,Jamie A. Murkey,Magrit Carlson,Paul M. Vespa,Tara Vijayan,Paul R Allyn,Shelley Campeau,Romney M. Humphries,Jeffrey D. Klausner,Czarina Ganzon,Fatemeh Memar,Nicolle Anne Ocampo,Lara Zimmermann,Stuart H. Cohen,Christopher R. Polage,Roberta L. DeBiasi,Barbara Haller,Ronald H. Dallas,Gabriela Maron,Randall T. Hayden,Kevin Messacar,Samuel R. Dominguez,Steve Miller,Charles Y. Chiu +42 more
TL;DR: Routine microbiologic testing is often insufficient to detect all neuroinvasive pathogens, so metagenomic NGS of CSF obtained from patients with meningitis or encephalitis improved diagnosis of neurologic infections and provided actionable information in some cases.
Journal ArticleDOI
A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study
Alexander L. Greninger,Samia N. Naccache,Kevin Messacar,Anna Clayton,Guixia Yu,Sneha Somasekar,Scot Federman,Doug Stryke,Christopher Anderson,Shigeo Yagi,Sharon Messenger,Debra A. Wadford,Dongxiang Xia,James Watt,Keith Van Haren,Samuel R. Dominguez,Carol A. Glaser,Grace M. Aldrovandi,Charles Y. Chiu +18 more
TL;DR: Findings strengthen the putative association between enterovirus D68 and acute flaccid myelitis and the contention that acute Flaccid Myelitis is a rare yet severe clinical manifestation of enterov virus D68 infection in susceptible hosts.
Journal ArticleDOI
Erratum to: Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing
Alexander L. Greninger,Kevin Messacar,Thelma Dunnebacke,Samia N. Naccache,Scot Federman,Jerome Bouquet,David M. Mirsky,Yosuke Nomura,Shigeo Yagi,Carol A. Glaser,Michael Vollmer,Craig A. Press,Bette K. Kleinschmidt-DeMasters,Samuel R. Dominguez,Charles Y. Chiu +14 more
TL;DR: This study presents a novel, scalable, and scalable approach that allows for real-time assessment of the impact of infectious disease-related adverse events on survival and quality of life at the clinic level.
Journal ArticleDOI
Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid
Steve Miller,Samia N. Naccache,Samia N. Naccache,Erik Samayoa,Kevin Messacar,Shaun Arevalo,Scot Federman,Doug Stryke,Elizabeth Pham,Becky Fung,William J. Bolosky,Danielle Ingebrigtsen,Walter Lorizio,Sandra M. Paff,John A. Leake,Rick L. Pesano,Roberta L. DeBiasi,Samuel R. Dominguez,Charles Y. Chiu +18 more
TL;DR: The analytic performance of a laboratory-validated mNGS assay for pan-pathogen detection, to be used clinically for diagnosis of neurological infections from CSF, is demonstrated.
Journal ArticleDOI
A cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA
Kevin Messacar,Teri Schreiner,John A Maloney,Adam Wallace,Jan Ludke,M Stephen Oberste,W. Allan Nix,Christine C. Robinson,Mary P. Glode,Mark J. Abzug,Samuel R. Dominguez +10 more
TL;DR: The findings suggest the possibility of an association between enterovirus D68 and neurological disease in children and development of effective antiviral or immunomodulatory therapies and vaccines should become scientific priorities.