D
Douglas L. Mayers
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 3
Citations - 1287
Douglas L. Mayers is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Prodrug. The author has an hindex of 3, co-authored 3 publications receiving 978 citations.
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Journal ArticleDOI
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren,Robert Jordan,Michael K. Lo,Adrian S. Ray,Richard L. Mackman,Veronica Soloveva,Dustin Siegel,Michel Perron,Roy Bannister,Hui Hon Chung,Nate Larson,Robert G. Strickley,Jay Wells,Kelly S. Stuthman,Sean A. Van Tongeren,Nicole L. Garza,Ginger Donnelly,Amy C. Shurtleff,Cary Retterer,Dima N. Gharaibeh,Rouzbeh Zamani,Tara Kenny,Brett P. Eaton,Elizabeth C. Grimes,Lisa S. Welch,Laura Gomba,Catherine L. Wilhelmsen,Donald K. Nichols,Jonathan E. Nuss,Elyse R. Nagle,Jeffrey R. Kugelman,Gustavo Palacios,Edward Doerffler,Sean Neville,Ernest Carra,Michael O. Clarke,Lijun Zhang,Willard Lew,Bruce Ross,Queenie Wang,Kwon Soo Chun,Lydia Wolfe,Darius Babusis,Yeojin Park,Kirsten M. Stray,Iva Trancheva,Joy Y. Feng,Ona Barauskas,Yili Xu,Pamela Wong,Molly R. Braun,Mike Flint,Laura K. McMullan,Shan Shan Chen,Rachel Fearns,S. Swaminathan,Douglas L. Mayers,Christina F. Spiropoulou,William A. Lee,Stuart T. Nichol,Tomas Cihlar,Sina Bavari +61 more
TL;DR: These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates, and the broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenavirus, and coronavirus suggests the potential for wider medical use.
Journal ArticleDOI
Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates
Travis K. Warren,Robert Jordan,Michale Lo,Veronica Soloveva,Adrian S. Ray,Roy Bannister,Richard L. Mackman,Michel Perron,Kirsten M. Stray,Joy Y. Feng,Yili Xu,Jay Wells,Kelly S. Stuthman,Lisa S. Welch,Edward Doerffler,Lijun Zhang,Kwon Soo Chun,Hui Hon Chung,Sean Neville,Willard Lew,Yeojin Park,Darius Babusis,Robert G. Strickley,Pamela Wong,S. Swaminathan,William A. Lee,Douglas L. Mayers,Tomas Cihlar,Sina Bavari +28 more
Journal ArticleDOI
Current status of chemically synthesized inhibitors of Ebola virus.
TL;DR: A number of antivirals, including AVI-6002, BCX4430, brincidofovir, favipiravir, and TKM-100802 are described and an update on their current status is given.