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Douglas N. Roberts
Researcher at Agilent Technologies
Publications - 19
Citations - 2131
Douglas N. Roberts is an academic researcher from Agilent Technologies. The author has contributed to research in topics: Histone H2A & Histone code. The author has an hindex of 13, co-authored 19 publications receiving 2017 citations. Previous affiliations of Douglas N. Roberts include Howard Hughes Medical Institute & University of Utah.
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Journal ArticleDOI
Genome-Wide Dynamics of Htz1, a Histone H2A Variant that Poises Repressed/Basal Promoters for Activation through Histone Loss
Haiying Zhang,Haiying Zhang,Douglas N. Roberts,Douglas N. Roberts,Bradley R. Cairns,Bradley R. Cairns +5 more
TL;DR: It is suggested that Htz1-bearing nucleosomes are deposited at repressed/basal promoters but facilitate activation through their susceptibility to loss, thereby helping to expose promoter DNA.
Journal ArticleDOI
Developmental programming of CpG island methylation profiles in the human genome
Ravid Straussman,Deborah Nejman,Douglas N. Roberts,Israel Steinfeld,Barak Blum,Nissim Benvenisty,Itamar Simon,Zohar Yakhini,Zohar Yakhini,Howard Cedar +9 more
TL;DR: It is shown that unmethylated regions (UMRs) seem to be formed during early embryogenesis, not as a result of CpG-ness, but rather through the recognition of specific sequence motifs closely associated with transcription start sites.
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Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors
Andrew J. Oler,Ravi K. Alla,Douglas N. Roberts,Alexander Wong,Peter C. Hollenhorst,Katherine J. Chandler,Patrick A Cassiday,Cassie A. Nelson,Curt H. Hagedorn,Barbara J. Graves,Bradley R. Cairns +10 more
TL;DR: Pol III localization in other transformed and primary cell lines reveals previously uncharacterized and cell type–specific Pol III loci as well as one microRNA, suggesting that active chromatin gates Pol III accessibility to the genome.
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A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control
Melinda L. Angus-Hill,Alisha Schlichter,Douglas N. Roberts,Hediye Erdjument-Bromage,Paul Tempst,Bradley R. Cairns +5 more
TL;DR: It is proposed that Rsc3 and Rsc30 interact physically but have different roles in targeting or regulating RSC, a yeast remodeler RSC complex that requires their zinc cluster domain.
Journal ArticleDOI
The RNA polymerase III transcriptome revealed by genome-wide localization and activity-occupancy relationships.
TL;DR: New aspects of the kinetics, dynamics, and targets of the Pol III system are revealed, including TATA box-binding protein occupancy was greater at Pol III targets than virtually all Pol II targets, and the highly occupied Pol II target targets are generally strongly transcribed.