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Itamar Simon
Researcher at Hebrew University of Jerusalem
Publications - 75
Citations - 13639
Itamar Simon is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Gene & Replication timing. The author has an hindex of 37, co-authored 68 publications receiving 13088 citations. Previous affiliations of Itamar Simon include University of Pittsburgh & Carnegie Mellon University.
Papers
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Journal ArticleDOI
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Tong Ihn Lee,Nicola J. Rinaldi,François Robert,Duncan T. Odom,Ziv Bar-Joseph,Georg K. Gerber,Nancy M. Hannett,Christopher T. Harbison,Craig M. Thompson,Itamar Simon,Julia Zeitlinger,Ezra G. Jennings,Heather L. Murray,D. Benjamin Gordon,Bing Ren,John J. Wyrick,Jean-Bosco Tagne,Thomas L. Volkert,Ernest Fraenkel,David K. Gifford,Richard A. Young +20 more
TL;DR: This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.
PatentDOI
Genome-wide location and function of dna binding proteins
TL;DR: In this paper, a method for identifying a set of genes where cell cycle regulator binding correlates with gene expression and identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.
Journal ArticleDOI
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
Yeshayahu Schlesinger,Ravid Straussman,Ilana Keshet,Shlomit Farkash,Merav Hecht,Joseph Zimmerman,Eran Eden,Zohar Yakhini,Zohar Yakhini,Etti Ben-Shushan,Benjamin Reubinoff,Yehudit Bergman,Itamar Simon,Howard Cedar +13 more
TL;DR: Using chromatin immunoprecipitation analysis, this paper showed that genes methylated in cancer cells are specifically packaged with nucleosomes containing histone H3 trimethylated on Lys27.
Journal ArticleDOI
Allelic inactivation regulates olfactory receptor gene expression.
TL;DR: This model, involving inactivation of one allelic array and cis control of the active array, provides a mechanism such that individual neurons express one or a small number of receptors.
Journal ArticleDOI
Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle
Itamar Simon,John D. Barnett,Nancy M. Hannett,Christopher T. Harbison,Nicola J. Rinaldi,Thomas L. Volkert,John J. Wyrick,Julia Zeitlinger,David K. Gifford,Tommi S. Jaakkola,Richard A. Young +10 more
TL;DR: Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators, and revealed how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events.